{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:41:30Z","timestamp":1784860890177,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012213","name":"Research Society for the Study of Diabetes in India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012213","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Deficiency of neurotropic factors is implicated in diabetic neuropathy (DN). Netrin\u20101 is a neurotropic factor, but its association with DN has not been explored. We have assessed the association between serum netrin\u20101 levels and early diabetic neuropathy assessed by quantifying corneal nerve fiber loss using corneal confocal microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 72 participants with type\u20092 diabetes, without and with corneal nerve fiber loss (DN\u2212 <jats:italic>n<\/jats:italic>\u2009=\u200942, DN+ <jats:italic>n<\/jats:italic>\u2009=\u200930), and 45 healthy controls were studied. Serum netrin\u20101 levels were measured by enzyme\u2010linked immunosorbent assay, and corneal nerve morphology was assessed using corneal confocal microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Corneal nerve fiber density, branch density, fiber length and serum netrin\u20101 levels were significantly lower in the DN\u2212 and DN+ groups compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Netrin\u20101 levels correlated with corneal nerve fiber length in the DN+ group (<jats:italic>r<\/jats:italic>\u2009=\u20090.51; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). A receiver operating characteristic curve analysis showed that a netrin\u20101 cut\u2010off value of 599.6 (pg\/mL) had an area under the curve of 0.85, with a sensitivity of 76% and specificity of 74% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; 95% confidence interval 0.76\u20130.94) for differentiating patients with and without corneal nerve loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum netrin\u20101 levels show a progressive decline with increasing severity of small nerve fiber damage in patients with diabetes. Netrin\u20101 could act as a biomarker for small nerve fiber damage in DN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14197","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T04:45:26Z","timestamp":1715316326000},"page":"1068-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Circulating netrin\u20101 levels are reduced and related to corneal nerve fiber loss in patients with diabetic neuropathy"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-0333","authenticated-orcid":false,"given":"Asif","family":"Mondal","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Post Graduate Medical Education and Research (IPGME&amp;R)  Kolkata West Bengal 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