{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:19:38Z","timestamp":1788941978493,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>\n                      Tanshinone\u2009IIA (TIIA) is one of the main components of the root of the red\u2010rooted\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                      Bunge. However, the molecular mechanisms underlying TIIA\u2010mediated protective effects in diabetic nephropathy (DN) are still unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      High glucose (HG)\u2010induced mouse podocyte cell line (MPC5) cells were used as the\n                      <jats:italic>in\u2009vitro<\/jats:italic>\n                      model of DN and treated with TIIA. Cell viability, proliferation and apoptosis were detected using 3\u2010(4, 5\u2010dimethylthiazolyl\u20102)\u20102, 5\u2010diphenyltetrazolium bromide, 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine and flow cytometry assays. The protein levels were assessed using western blot assay. The levels of inflammatory factors were deleted by enzyme\u2010linked immunoassay. Fe\n                      <jats:sup>+<\/jats:sup>\n                      level, reactive oxygen species, malondialdehyde and glutathione products were detected using special assay kits. After ENCORI prediction, the interaction between embryonic lethal abnormal visual\u2010like protein\u20091 (ELAVL1) and acyl\u2010coenzyme\u2009A synthetase long\u2010chain family member\u20094 (ACSL4) was verified using co\u2010immunoprecipitation assay and dual\u2010luciferase reporter assays. ACSL4 messenger ribonucleic acid expression was measured using real\u2010time quantitative polymerase chain reaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TIIA repressed HG\u2010induced MPC5 cell apoptosis, inflammatory response and ferroptosis. ACSL4 upregulation relieved the repression of TIIA on HG\u2010mediated MPC5 cell injury and ferroptosis. ELAVL1 is bound with ACSL4 to positively regulate the stability of ACSL4 messenger ribonucleic acid. TIIA hindered HG\u2010triggered MPC5 cell injury and ferroptosis by regulating the ELAVL1\u2013ACSL4 pathway. TIIA blocked DN progression in\n                      <jats:italic>in\u2009vivo<\/jats:italic>\n                      research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TIIA treatment restrained HG\u2010caused MPC5 cell injury and ferroptosis partly through targeting the ELAVL1\u2013ACSL4 axis, providing a promising therapeutic target for DN treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.14206","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:39:59Z","timestamp":1713832799000},"page":"1003-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Tanshinone\u2009\n                    <scp>IIA<\/scp>\n                    suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual\u2010like protein\u20091 and acyl\u2010coenzyme\u2009A synthetase long\u2010chain family member\u20094 signaling pathway"],"prefix":"10.1111","volume":"15","author":[{"given":"Shuai","family":"Zhu","sequence":"first","affiliation":[{"name":"Graduate School Xinxiang Medical University  Xinxiang China"},{"name":"Department of Endocrinology and Metabolism Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8410-1688","authenticated-orcid":false,"given":"Zhiqiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhengzhou 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