{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:13:30Z","timestamp":1771478010885,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vascular adhesion protein\u20101 (VAP\u20101) plays a dual role with its adhesive and enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing the breakdown of primary amines into harmful by\u2010products, which are linked to diabetic complications. Present in various tissues, VAP\u20101 also circulates in a soluble form in the bloodstream. Diabetes is associated with several complications such as cardiovascular disease, retinopathy, nephropathy, and neuropathy, significantly contributing to disability and mortality. These complications arise from hyperglycemia\u2010induced oxidative stress, inflammation, and the formation of advanced glycation end\u2010products (AGEs). Earlier research, including our own from the 1990s and early 2000s, has underscored the critical role of VAP\u20101 in these pathological processes, prompting extensive investigation into its contribution to diabetic complications. In this review, we examine the involvement of VAP\u20101 in diabetes and its complications, alongside its link to other conditions related to diabetes, such as cancer and metabolic dysfunction\u2010associated fatty liver disease. We also explore the utility of soluble VAP\u20101 as a biomarker for diabetes, its complications, and other related conditions. Since the inhibition of VAP\u20101 to treat diabetic complications is a novel and promising treatment option, further studies are needed to translate the beneficial effect of VAP\u20101 inhibitors observed in animal studies to clinical trials recruiting human subjects. Besides, future studies should focus on using serum sVAP\u20101 levels for risk assessment in diabetic patients, identifying those who need intensive glycemic control, and determining the patient population that would benefit most from VAP\u20101 inhibitor therapies.<\/jats:p>","DOI":"10.1111\/jdi.14209","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T08:29:25Z","timestamp":1712392165000},"page":"982-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The role of vascular adhesion protein\u20101 in diabetes and diabetic complications"],"prefix":"10.1111","volume":"15","author":[{"given":"I\u2010Weng","family":"Yen","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine National Taiwan University Hospital Hsin\u2010Chu Branch  Hsinchu 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