{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:26:23Z","timestamp":1747185983758,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Despite the emergence of new drugs with novel mechanisms of action, treatment options for older people and those with chronic kidney disease are still limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Using a medical database compiled from Diagnostic Procedure Combination hospitals, we retrospectively analyzed treatment status, glycemic control and kidney function over 3\u2009years after the first oral antidiabetic drugs in Japanese adults with type\u20092 diabetes who were aged \u226565\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 5,434 study participants, 3,246 (59.7%) were men, the median age was 72.0\u2009years, the baseline median hemoglobin A1c was 7.1% and the baseline median estimated glomerular filtration rate was 66.6\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. Treatment was intensified in 40.0% of people during the 3\u2010year observation period, and the median time to the first treatment intensification was 198\u2009days. Insulin was the most commonly used agent for treatment intensification (36.9%, 802\/2,175). Hemoglobin A1c of &lt;7.0% was achieved in 3,571 (65.7%) at 360\u2009\u00b1\u200990\u2009days. Multivariable logistic regression analysis found that baseline age, hemoglobin A1c and estimated glomerular filtration rate were negatively associated with achieving hemoglobin A1c of &lt;7.0% at 360\u2009\u00b1\u200990\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In older Japanese adults with type\u20092 diabetes, those with a lower estimated glomerular filtration rate were more likely to achieve hemoglobin A1c of &lt;7.0%. To safely manage blood glucose levels in older adults with chronic kidney disease, physicians should remain vigilant about the risk of iatrogenic hypoglycemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14214","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T10:04:37Z","timestamp":1713434677000},"page":"1057-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medical database analysis of the association between kidney function and achievement of glycemic control in older Japanese adults with type\u20092 diabetes who started with oral antidiabetic drugs"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-6906","authenticated-orcid":false,"given":"Ryo","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Diabetes, Metabolism and Endocrinology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoyasu","family":"Kazumori","sequence":"additional","affiliation":[{"name":"Medical Science, Sumitomo Pharma Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Usui","sequence":"additional","affiliation":[{"name":"Medical Science, Sumitomo Pharma Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Data Science Division Real\u2010World Evidence Department INTAGE Healthcare Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.01.070"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12956"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.136"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.460"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4533"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-016-0293-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2011.00808.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1801"},{"key":"e_1_2_7_10_1","unstructured":"The International Diabetes Federation.Global guideline for managing older people with type 2 diabetes. 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