{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:04Z","timestamp":1791919024302,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Diabetes has been related to an increased risk of oral cancer. Nevertheless, the impact of diabetes on the outcome of individuals with oral and oropharyngeal cancer is not clear. In this study, a meta\u2010analysis was carried out to assess the link between diabetes and the survival of individuals with oral and oropharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Relevant cohort studies for the meta\u2010analysis objective were obtained through searching electronic databases, such as PubMed, Web of Science and Embase. The data were combined using a random effects model that accounted for differences between studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 cohorts involving 21,871 patients with oral and oropharyngeal cancer were included. Pooled results suggest that compared with those with normoglycemia, oral and oropharyngeal cancer patients with diabetes were associated with a poor overall survival (hazard ratio 1.69, 95% confidence interval 1.29\u20132.22, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200969%). Subgroup analysis suggested a stronger association between diabetes and poor overall survival in patients aged \u226552\u2009years as compared with those aged &lt;52\u2009years (hazard ratio 2.08 vs 1.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Other study characteristics, such as study country, tumor stage or follow\u2010up duration, did not seem to significantly affect the association (<jats:italic>P<\/jats:italic> for subgroup difference all &gt;0.05). In addition, diabetes was also associated with a poor progression\u2010free survival of patients with oral and oropharyngeal cancer (hazard ratio 1.61, 95% confidence interval 1.30\u20131.99, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20099%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with oral and oropharyngeal cancer might have a poor survival if they have pre\u2010existing diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14223","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T15:09:47Z","timestamp":1715353787000},"page":"1140-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of diabetes on the prognosis of patients with oral and oropharyngeal cancer: A meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First People's Hospital of Lianyungang  Lianyungang Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First People's Hospital of Lianyungang  Lianyungang Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8300-0829","authenticated-orcid":false,"given":"Laijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First People's Hospital of Lianyungang  Lianyungang Jiangsu Province 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