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We used disproportionality and Bayesian analysis to examine clinical and demographic attributes, trends reported quarterly, and contrasts between two distinct indications (obesity and type 2 diabetes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 10 unexpected adverse signals related to \u201cpancreatic cancer\u201d, \u201cintestinal obstruction\u201d, \u201ccholecystitis\u201d, and \u201cpolycystic ovary\u201d and both the two different indications had the same serious adverse reaction events occurring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified many unexpected signals of serious adverse reactions, suggesting the importance of continuous post\u2010marketing surveillance of semaglutide to understand its potential 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