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The heart rate variability parameters to evaluate cardiac autonomic function, and the indices for the assessment of cardiac structure and left ventricular (LV) diastolic function, including left atrium, LV posterior wall thickness, interventricular septum and <jats:italic>E<\/jats:italic>\/<jats:italic>e<\/jats:italic>\u2032 ratio, were measured or calculated. Propensity score matching was used for the sensitivity analysis to minimize potential imbalance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both the crude and propensity score matching analyses, significant differences were observed in heart rate variability between individuals with and without DF, as evidenced by lower standard deviation of the normal sinus interval, lower low\u2010frequency power\/high\u2010frequency power ratio, lower standard deviation of the 5\u2010min average RR intervals, lower low\u2010frequency power, lower percentage of normal adjacent RR interval difference &gt;50\u2009ms, lower root mean square of successive RR interval differences and lower high\u2010frequency power (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In multivariate analysis, DF showed an independent negative correlation with the aforementioned indices of heart rate variability (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Individuals with DF showed higher left atrium, LV posterior wall thickness, interventricular septum and a higher <jats:italic>E<\/jats:italic>\/<jats:italic>e<\/jats:italic>\u2032 ratio than those without DF in the crude analysis (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), whereas these indices were no longer associated with DF in the multivariate analysis and the propensity score matching analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiac autonomic modulation was more severely impaired in individuals with DF than in their counterparts without DF. There has been insufficient evidence to demonstrate the independent association of DF and LV diastolic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14250","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T16:54:57Z","timestamp":1718124897000},"page":"1276-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac electrophysiology, structure and diastolic function in patients with diabetic foot versus those without diabetic foot"],"prefix":"10.1111","volume":"15","author":[{"given":"Mingxin","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic Foot Care Center, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic 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