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Exogenous multiple\u2010daily insulin injections are most commonly prescribed for patients with type\u20091 diabetes mellitus. However, exogenous insulin supply often fails to cope with real\u2010time changing life\u2010log variables, such as activity, diet and stress, which results in recurrent hypo\u2010 and hyperglycemia in patients with type\u20091 diabetes mellitus. Islet transplantation is an ideal method to treat patients with type\u20091 diabetes mellitus, as it can restore the endogenous capacity of glucose\u2010stimulated insulin secretion. However, due to donor scarcity and technical barriers, only a limited number of islet transplantations have been carried out in Asia, including South Korea. Since 2013, our center has carried out two allogenic islet transplantations, with one case leading to near total insulin independence after one\u2010to\u2010one islet transplantation. Although the other patient failed to restore endogenous insulin production, there was a remarkable improvement in hypoglycemia. We speculate that islet transplantation remains an important and ideal treatment option for patients with type\u20091 diabetes mellitus who suffer from recurrent severe hypoglycemia.<\/jats:p>","DOI":"10.1111\/jdi.14264","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T13:56:10Z","timestamp":1722952570000},"page":"1165-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Islet transplantation in Korea"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0533-9786","authenticated-orcid":false,"given":"Joonyub","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Seoul St Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-2208","authenticated-orcid":false,"given":"Kun\u2010Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Seoul St Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00378.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430401"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13884"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2015.30.7.991"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(01)00366-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000158427.07084.C5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000217"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X636885"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2023.0282"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0942-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0156"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0212"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2022.1440"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2023.1765"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-36711-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.726"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69703-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00082-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00114-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2022.0386"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205225"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004736"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907863"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0212-y"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05568-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.040"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.08.034"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2631-z"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.10.003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100466"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.101958"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00790-4"},{"key":"e_1_2_6_34_1","unstructured":"Vertex presents positive VX\u2010880 results from ongoing phase 1\/2 study in Type 1 diabetes at the American Diabetes Association 83rd Scientific Sessions. 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