{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:51:34Z","timestamp":1778975494255,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030953","name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology","doi-asserted-by":"publisher","award":["The 2021 Research Grant Award (R21\u2010012)"],"award-info":[{"award-number":["The 2021 Research Grant Award (R21\u2010012)"]}],"id":[{"id":"10.13039\/100030953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To investigate whether sarcopenic obesity is associated with the progression of atherosclerotic lesions in older patients with diabetes and to identify the obesity components of sarcopenic obesity that best reflect atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In 118 inpatients aged \u226575\u2009years with diabetes mellitus, sarcopenia defined as a low skeletal muscle mass and low grip strength was assessed, and sarcopenia coexisting with a high body\u2010fat percentage or visceral fat area was defined as sarcopenic obesity. Correlations between the obesity components and atherosclerotic markers, including the carotid intima\u2010media thickness, were analyzed; the intima\u2010media thickness was analyzed in four groups with and without obesity and sarcopenia, and a multiple linear regression analysis adjusted for covariates was conducted to investigate whether sarcopenic obesity was independently associated with the intima\u2010media thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The visceral fat area and intima\u2010media thickness showed positive correlations in the overall patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.032) and the sarcopenia (<jats:italic>P<\/jats:italic>\u2009=\u20090.016) group but showed no associations in participants without sarcopenia. The intima\u2010media thickness in the group showing sarcopenia with a high visceral fat area was significantly higher than that in the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.012). Sarcopenic obesity defined by a high body\u2010fat percentage and high visceral fat area was independently associated with the intima\u2010media thickness even after adjusting for age, sex, and atherogenic risk factors. However, sarcopenic obesity defined by a high visceral fat area was more strongly associated with the intima\u2010media thickness (\u03b2\u2009=\u20090.384, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) than that defined by the high body\u2010fat percentage (\u03b2\u2009=\u20090.237, <jats:italic>P<\/jats:italic>\u2009=\u20090.068).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenic obesity, especially that defined by visceral fat accumulation, reflected the risk of atherosclerotic lesion progression in older patients with diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14274","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:39:11Z","timestamp":1722933551000},"page":"1510-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Coexistence of high visceral fat area and sarcopenia is associated with atherosclerotic markers in old\u2010old patients with diabetes: A cross\u2010sectional study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-5648","authenticated-orcid":false,"given":"Motoya","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-3319","authenticated-orcid":false,"given":"Yoshiaki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi\u2010ku Tokyo Japan"},{"name":"The Center for Comprehensive Care and Research for Prefrailty Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi\u2010ku Tokyo 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