{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:28:29Z","timestamp":1771331309653,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>We evaluated the 24\u2010h ambulatory blood pressure monitoring data of patients to investigate the relationship between the progression of diabetic polyneuropathy and impaired circadian blood pressure variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included 154 patients with diabetes who were hospitalized for hyperglycemic control. Routine biochemical and hematological tests, ambulatory blood pressure monitoring, screening for diabetic complications, nerve conduction studies, and Holter electrocardiography were carried out on all patients. They were classified according to the Baba classification and the clinical staging for diabetic polyneuropathy, and their ambulatory blood pressure monitoring data were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients were classified into stages 0 (<jats:italic>n<\/jats:italic>\u2009=\u200964), I (<jats:italic>n<\/jats:italic>\u2009=\u200942), II (<jats:italic>n<\/jats:italic>\u2009=\u200924), III (<jats:italic>n<\/jats:italic>\u2009=\u200911) and IV (<jats:italic>n<\/jats:italic>\u2009=\u200913) according to the Baba classification. As the severity of diabetic polyneuropathy progressed, the degree of nocturnal blood pressure reduction decreased and the percentage of patients with riser\u2010type impaired circadian blood pressure variability increased. Similar results were observed in patients classified according to the clinical staging for diabetic polyneuropathy. In the multivariate logistic regression analysis, the severity of diabetic neuropathy and urinary albumin excretion were independently associated with the percentage of patients with riser\u2010type. However, the adjusted odds ratio was the highest for Baba class\u2009I and decreased with increasing severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with progressive diabetic polyneuropathy and renal impairment often show impaired circadian blood pressure variability. The progression of electrophysiological and clinical neuropathy is associated with riser\u2010type circadian blood pressure variability independent of urinary albumin excretion, insulin therapy, renin\u2013angiotensin\u2013aldosterone system inhibitor medication and body mass index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14282","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:45:18Z","timestamp":1734590718000},"page":"463-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship between the progression of diabetic polyneuropathy and impaired circadian blood pressure variability"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2152-782X","authenticated-orcid":false,"given":"Dai","family":"Yamagami","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrine Medicine Kagoshima University Graduate School of Medicine and Dental Sciences  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4769-2193","authenticated-orcid":false,"given":"Takahisa","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrine Medicine Kagoshima University Graduate School of Medicine and Dental Sciences  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Arimura","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrine Medicine Kagoshima University Graduate School of Medicine and Dental Sciences  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrine Medicine Kagoshima University Graduate School of Medicine and Dental Sciences  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.19.SupplementI_S1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.10.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.614313"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1002162"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/6.1.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199606)13:6<531::AID-DIA115>3.0.CO;2-J"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.9.1501"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.05.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00419.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.115329"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/7.9.808"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-012-0323-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.14.4.367"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.06.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0828"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1108-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.4.861"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.11.1281"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13173"},{"key":"e_1_2_7_21_1","first-page":"71","article-title":"Severity granding system of diabetic neuropathy in type\u20102 diabetes by nerve conduction study: Five\u2010year prospective study on occurrence of diabetic foot, macroangiopathic events, and eventual death","volume":"46","author":"Baba M","year":"2018","journal-title":"Jpn J Clin Neurophysiol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.01.053"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.09.026"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1823"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.141.Suppl_479"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.6.1276"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.6.578"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199305000-00015"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.47"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1553"},{"key":"e_1_2_7_32_1","first-page":"95","article-title":"The natural history of diabetic autonomic neuropathy","volume":"49","author":"Ewing DJ","year":"1980","journal-title":"Q J Med"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-002040"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.14282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:49:52Z","timestamp":1741765792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.14282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jdi.14282"],"URL":"https:\/\/doi.org\/10.1111\/jdi.14282","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"2024-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}