{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:20:01Z","timestamp":1788816001524,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the prevalence of GDM and pregnancy outcomes between the one\u2010step and two\u2010step methods of universal screening among Thai pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized controlled trial was conducted on singleton Thai pregnant women at a gestational age of 24\u201328\u2009weeks. They were randomly assigned to either the one\u2010step method group (a universal 75\u2010gm 2\u2010h oral glucose tolerance test: OGTT) or the two\u2010step method group (a universal 50\u2010gm oral glucose challenge test followed by a 100\u2010gm 3\u2010h OGTT). The women received standard antenatal care. The prevalence of GDM and obstetric outcomes were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 143 women meeting the inclusion criteria were randomly allocated into the one\u2010step group (72 cases) and the two\u2010step group (71 cases). The prevalence of GDM was significantly higher in the one\u2010step group than in the two\u2010step group, with rates of 24\/73 (33.3%) vs 8\/70 (11.3%); <jats:italic>P<\/jats:italic> value 0.002; relative risk of 2.96, 95% CI: 1.43\u20136.14, respectively. Demographic data and maternal and neonatal outcomes were comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The one\u2010step method can markedly increase the prevalence of GDM to nearly three times that of the two\u2010step method, leading to a substantial increase in care costs and burdens without clear benefits. Convincingly, the one\u2010step method as a new approach may not be suitable for universal screening in a busy antenatal care setting, especially in low\u2010resource health centers in developing countries or among populations with a high prevalence of GDM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14370","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T13:13:53Z","timestamp":1732799633000},"page":"728-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of universal screening for gestational diabetes mellitus between one\u2010step and two\u2010step method among Thai pregnant women: A randomized control trial"],"prefix":"10.1111","volume":"16","author":[{"given":"Natthaphon","family":"Phoblap","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai 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