{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:24:49Z","timestamp":1791815089831,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013277","name":"National Clinical Key Specialty Project Foundation","doi-asserted-by":"publisher","award":["3030294002"],"award-info":[{"award-number":["3030294002"]}],"id":[{"id":"10.13039\/501100013277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400978"],"award-info":[{"award-number":["82400978"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000790"],"award-info":[{"award-number":["82000790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200949"],"award-info":[{"award-number":["82200949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound\u2010healing processes. Interleukin\u201037 (IL\u201037) is a natural suppressor of innate inflammation. Here, we aim to investigate the potential of IL\u201037 in enhancing the healing process of diabetic wounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The skin samples of DFU and non\u2010diabetic patients during foot and ankle orthopedic surgery were collected. The IL\u201037 transgenic mice (IL\u201037Tg) were created using CRISPR\/Cas\u2010mediated genome engineering. Mice were administered streptozotocin (STZ, 150\u2009mg\/kg) to induce a diabetic model. After 4\u2009weeks, an equidistant full\u2010thickness excisional wound measuring 8\u2009mm was created on the central back of each mouse and allowed to heal naturally. Body weight and blood glucose levels were measured weekly. The wound area was measured, and skin samples were collected on Day 10 for further Quantitative polymerase chain reaction (qPCR) and WB detection and RNA sequencing analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proinflammation cytokines such as TNF\u2010\u03b1 and IL\u20101\u03b2 and the MAPK signaling pathway were significantly increased in the wound margin of DFU patients. Compared with diabetic mice, diabetic IL\u201037Tg mice showed a significantly accelerated healing process. The enriched signaling pathways in RNA sequencing included cytokine\u2013cytokine receptor interaction, TNF signaling pathway, and NOD\u2010like receptor signaling pathway. Through QPCR and WB detection, we found that IL\u201037 could inhibit the activated MAPK and NOD\u2010like signaling pathway, reducing TNF\u2010\u03b1, IL\u20101\u03b2, and NLRP3 expression in the diabetic wound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IL\u201037 promotes skin wound healing in diabetic mice, providing a new possible target for treating diabetic wounds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14389","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T13:24:32Z","timestamp":1734960272000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin\u201037 promotes wound healing in diabetic mice by inhibiting the <scp>MAPK<\/scp>\/<scp>NLRP3<\/scp> pathway"],"prefix":"10.1111","volume":"16","author":[{"given":"Qiaoli","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Worldwide Medical Center, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolin","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Huashan Hospital Fudan University  Shanghai 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Nursing, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-2176","authenticated-orcid":false,"given":"Hangping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Huashan Hospital Fudan University  Shanghai 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