{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:00:23Z","timestamp":1777968023856,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018684","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["WKZX2022JG0111"],"award-info":[{"award-number":["WKZX2022JG0111"]}],"id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["K2023063"],"award-info":[{"award-number":["K2023063"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["MS2022141"],"award-info":[{"award-number":["MS2022141"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To investigate the predictive value of the biliverdin reductase\u2010A (BVR\u2010A) and the homeostasis model assessment for insulin resistance (HOMA\u2010IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to establish a nomogram model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included 140 patients with type 2 diabetes mellitus. Based on Montreal Cognitive Assessment (MoCA) scores, participants were categorized into the normal cognitive function (T2DM\u2010NCF) group (65 cases) and the mild cognitive impairment (T2DM\u2010MCI) group (75 cases). Multivariate logistic regression analysis was performed to identify the factors associated with MCI in patients with type 2 diabetes mellitus. A nomogram prediction model was developed using R software for the selected factors, and its predictability and accuracy were verified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the T2DM\u2010NCF group, subjects with MCI were older, had a longer duration of diabetes, higher HOMA\u2010IR, lower BVR\u2010A, lower cognitive scores, and lower education levels (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate logistic regression analysis showed that duration of diabetes (OR\u2009=\u20091.407, 95% CI: 1.163\u20131.701), HOMA\u2010IR (OR\u2009=\u20091.741, 95% CI: 1.197\u20132.53), and BVR\u2010A (OR\u2009=\u20090.528, 95% CI: 0.392\u20130.712) were significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The C\u2010index of the nomogram was 0.863 (95% CI: 0.752\u20130.937).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that BVR\u2010A and HOMA\u2010IR are significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The nomogram incorporating BVR\u2010A and HOMA\u2010IR aids in predicting the risk of developing MCI in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.70020","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:36:56Z","timestamp":1741772216000},"page":"936-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive value of biliverdin reductase\u2010A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes"],"prefix":"10.1111","volume":"16","author":[{"given":"Li","family":"Shen","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Wei","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haorui","family":"Lv","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Genetics Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aifang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Macau  Macao SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-0265","authenticated-orcid":false,"given":"Changjiang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30405-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13545"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00690-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01648-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0048-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104642"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.09.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239091"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.07.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087282"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.12.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.07.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1231-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abh3066"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.02.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.741263"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010111"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108499"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-023-01211-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"issue":"1","key":"e_1_2_8_23_1","first-page":"S111","article-title":"6. 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