{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:51Z","timestamp":1792512891257,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>No studies have specifically examined the effects of finerenone in treating type 2 diabetes patients with chronic kidney disease (CKD) and microalbuminuria. This study aimed to evaluate the effectiveness of finerenone in this group of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective real\u2010world study (ChiCTR2400087169) included type 2 diabetes outpatients with CKD from the Peking University First Hospital between March 2023 and March 2024. All patients in this study had a urinary albumin\u2010to\u2010creatinine ratio (UACR) of 30\u2013299\u2009mg\/g. The effects of finerenone were assessed by comparing UACR, HbA1c, creatinine, serum potassium, eGFR, and blood pressure at baseline and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients (39 males and 25 females), with a median age of 65.75\u2009years and a median duration of T2DM of 15.21\u2009years, were included. The baseline median UACR was 100.50\u2009mg\/g, significantly decreased to 61.27\u2009mg\/g (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at 3\u2009months and 62.49\u2009mg\/g (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at 6\u2009months after treatment. None of the other parameters differed significantly. Finerenone alone or in combination with ABS inhibitors, SGLT2 inhibitors, or GLP\u20101 agonists did not result in significant differences in UACR reduction. Patients with a &gt;30% UACR decrease had significantly higher baseline systolic blood pressure (SBP) than those with a \u226430% decrease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, baseline SBP significantly decreased after 6\u2009months of treatment in patients with a &gt;30% UACR reduction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Finerenone is effective in treating type 2 diabetes with CKD and microalbuminuria. Improved SBP control leads to a greater UACR reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.70023","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T03:39:52Z","timestamp":1742009992000},"page":"1028-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real\u2010world study"],"prefix":"10.1111","volume":"16","author":[{"given":"Yiming","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing 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