{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:37:13Z","timestamp":1774064233190,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Type 1 diabetes mellitus (T1DM) is a significant global health issue, particularly due to its association with microvascular complications such as diabetic peripheral neuropathy (DPN). Sensory nerves in the lower extremities are primarily affected by DPN, with the sural nerve being particularly impacted. The conventional method for diagnosing DPN involves evaluating four motor and four sensory nerves in the upper and lower extremities. Motor tests use dual\u2010point high\u2010intensity stimulation to elicit a compound muscle action potential, while sensory tests apply a single, lower\u2010intensity stimulus to assess depolarized nerve fibers. The aim of this study was to define the efficacy of using a single sural nerve response for the diagnosis of DPN in pediatric T1DM patients compared to the conventional method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed data from 242 patients, including 204 with T1DM and 38 controls. For T1DM patients, we evaluated risk factors for DPN, including age, gender, hemoglobin A1c levels, lipid parameters, and body mass index. Nerve conduction studies were evaluated in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The examination of a single sural nerve achieved a sensitivity of 83.3% and a specificity of 97.2% in diagnosing DPN. Multivariate logistic regression analysis identified HbA1c level as the only significant predictor of DPN. Comparison of sural nerve responses between non\u2010neuropathic T1DM patients and the control group indicated pre\u2010electrophysiological nerve abnormalities within the T1DM cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evaluation of a single sural nerve response in pediatric T1DM patients can replace conventional nerve studies. The study supports the use of point\u2010of\u2010care devices for DPN detection, potentially simplifying and enhancing clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.70030","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:36:55Z","timestamp":1742456215000},"page":"1050-1054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single sural nerve response: A reliable and practical method for diagnosis of diabetic peripheral neuropathy in children with type 1 diabetes"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-8372","authenticated-orcid":false,"given":"H\u00fcseyin Bahad\u0131r","family":"\u015eenol","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-2309","authenticated-orcid":false,"given":"\u00d6zge Y\u0131ld\u0131r\u0131m","family":"\u015ealba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-4206","authenticated-orcid":false,"given":"Elif Naz","family":"Kadem","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4078-1422","authenticated-orcid":false,"given":"Mustafa","family":"Halk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-3249","authenticated-orcid":false,"given":"Ay\u015fe \u0130pek","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-2857","authenticated-orcid":false,"given":"Adem","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8020-4884","authenticated-orcid":false,"given":"Ay\u015fe Semra","family":"H\u0131z","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-2422","authenticated-orcid":false,"given":"Korcan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-1411","authenticated-orcid":false,"given":"Ulu\u00e7","family":"Yi\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eylul University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107842"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31320-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2017.10.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pediatric16030064"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3178"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401840"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043554"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-01850-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04323-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2017.07.001"},{"key":"e_1_2_9_12_1","first-page":"351","article-title":"Painless Footdrop in a child with newly diagnosed type 1 diabetes mellitus: Case report","volume":"16","author":"Jafari M","year":"2024","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058783"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12583"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20233"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.05.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9993(93)90112-N"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1074"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13568"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13444"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13455"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26499"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00636.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2006.00208.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03685.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1601-183"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13153"},{"key":"e_1_2_9_28_1","first-page":"83","article-title":"Peripheral neuropathy in children and adolescents with insulin\u2010dependent diabetes mellitus","volume":"12","author":"Ghaemi N","year":"2018","journal-title":"Iran J Child Neurol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.28068"},{"key":"e_1_2_9_30_1","unstructured":"https:\/\/www.dpncheck.com."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13007"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:14:12Z","timestamp":1754914452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jdi.70030"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70030","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]},"assertion":[{"value":"2025-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}