{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:35:12Z","timestamp":1778250912592,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["5\u2010COE\u20102019\u2010861\u2010S\u2010B"],"award-info":[{"award-number":["5\u2010COE\u20102019\u2010861\u2010S\u2010B"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R00DK129785"],"award-info":[{"award-number":["R00DK129785"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK107956"],"award-info":[{"award-number":["R01DK107956"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK115687"],"award-info":[{"award-number":["R01DK115687"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK129320"],"award-info":[{"award-number":["R01DK129320"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK130913"],"award-info":[{"award-number":["R01DK130913"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007725","name":"Madras Diabetes Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The effect of diabetes subtypes on neuropathy prevalence and metabolic drivers of this relationship are unknown. Using electronic medical records from 50 diabetes care centers in eight states of India with biothesiometer and complete phenotyping data on 22,348 patients, we determined neuropathy prevalence stratified by India\u2010specific diabetes subtypes and evaluated associations with neuropathy (biothesiometer). Neuropathy prevalence was highest in severe insulin\u2010deficient diabetes (SIDD; 25.5%), followed by insulin\u2010resistant obese diabetes (IROD; 21.8%), mild age\u2010related diabetes (MARD; 18.9%), and combined insulin\u2010resistant and deficient diabetes (CIRDD; 17.3%, <jats:italic>P<\/jats:italic>\u2009=\u2009&lt;0.001). HbA1c (odds ratio [OR]: 1.19, 1.16\u20131.21), diabetes duration (OR: 1.04, 1.04\u20131.05), and waist circumference (OR: 1.01, 1.01\u20131.02) were associated with neuropathy. SIDD (OR: 2.23, 2.01\u20132.47), CIRDD (OR: 1.89, 1.69\u20132.11), and IROD (OR: 1.84, 1.66\u20132.04) had increased neuropathy compared to MARD. In India, SIDD patients are more likely to have neuropathy compared to MARD patients likely from longer diabetes duration and higher HbA1c; therefore, interventions should focus on hyperglycemia. Interventions in CIRDD and IROD patients should likely address obesity as well.<\/jats:p>","DOI":"10.1111\/jdi.70033","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T04:58:57Z","timestamp":1743310737000},"page":"1045-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe insulin\u2010deficient diabetes is at the opposite end of the neuropathy spectrum to mild aged\u2010related diabetes"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-6748","authenticated-orcid":false,"given":"Brian C","family":"Callaghan","sequence":"first","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit Mohan","family":"Anjana","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavanya","family":"Muthukumar","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan L","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jebarani","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani Arun","family":"Vignesh","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aswin","family":"Mukundan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva L","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viswanathan","family":"Mohan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre  Chennai 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