{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:12:13Z","timestamp":1785190333061,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Early\u2010onset type 2 diabetes mellitus (EOD), defined as a metabolic disorder diagnosed before the age of 40, with higher risks of complications, vascular events, and mortality, poses a significant threat to public health. Its prevalence has risen markedly in overweight populations in recent years, yet the underlying mechanisms remain elusive. Emerging evidence highlights a close association between gut microbiota (GM) and metabolic disorders, suggesting that modulating gut microbial dysbiosis may serve as a potential strategy for preventing and managing overweight EOD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this study, we enrolled 30 overweight EOD patients and 30 healthy controls, analyzing their GM profiles and correlations using physicochemical clinical parameters and fecal metabolites.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The results demonstrated significant differences in GM composition between overweight EOD patients and healthy controls. EOD patients exhibited increased the ratio of\n Firmicutes<\/jats:italic>\n \/\n Bacteroidetes<\/jats:italic>\n at the phylum level. At the genus level,\n Bilophila<\/jats:italic>\n ,\n Serratia<\/jats:italic>\n ,\n Lachnospira<\/jats:italic>\n , and\n Parabacteroides<\/jats:italic>\n were enriched in EOD patients, while taxa, such as\n Faecalibacterium<\/jats:italic>\n ,\n Ruminococcaceae<\/jats:italic>\n , and\n Clostridia_UCG\u2010014<\/jats:italic>\n , showed significant depletion. Correlation analyses revealed that\n Clostridia_UCG\u2010014<\/jats:italic>\n abundance was negatively associated with body mass index (BMI) (\n P<\/jats:italic>\n \u2009<\u20090.05), waist\u2010to\u2010height ratio (WHtR) (\n P<\/jats:italic>\n \u2009<\u20090.05), fasting plasma glucose (FPG) (\n P<\/jats:italic>\n \u2009<\u20090.05), low\u2010density lipoprotein cholesterol (LDL\u2010C) (\n P<\/jats:italic>\n \u2009<\u20090.05), and triglycerides (TG) (\n P<\/jats:italic>\n \u2009<\u20090.05), but positively correlated with high\u2010density lipoprotein cholesterol (HDL\u2010C) (\n P<\/jats:italic>\n \u2009<\u20090.05). Conversely,\n Bilophila<\/jats:italic>\n abundance displayed positive correlations with BMI (\n P<\/jats:italic>\n \u2009<\u20090.05), WHtR (\n P<\/jats:italic>\n \u2009<\u20090.05), FPG (\n P<\/jats:italic>\n \u2009<\u20090.05), LDL\u2010C (\n P<\/jats:italic>\n \u2009<\u20090.05), and TG (\n P<\/jats:italic>\n \u2009<\u20090.05). Meanwhile, biofilm formation (\n Escherichia coli<\/jats:italic>\n ), nitrogen metabolism, arginine and proline metabolism, beta\u2010lactam resistance, drug metabolism (other enzymes), glycerolipid metabolism and sucrose metabolism showed decreases in overweight EOD patients, respectively (\n P<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results indicate that\n Bilophila<\/jats:italic>\n and\n Clostridia_UCG\u2010014<\/jats:italic>\n may serve as microbial biomarkers for the identification of obesity\u2010related EOD.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdi.70074","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T02:38:56Z","timestamp":1754361536000},"page":"1890-1899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research on the characteristics of gut microbiota in overweight patients with early\u2010onset type 2 diabetes mellitus"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-0677","authenticated-orcid":false,"given":"Ke","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ma","sequence":"additional","affiliation":[{"name":"Xinxiang Medical University Xin Xiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shousen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3258-3436","authenticated-orcid":false,"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Xinjiang Medical University Urumqi China"},{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-3079","authenticated-orcid":false,"given":"Yanfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang 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