{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:28:08Z","timestamp":1773995288000,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>In patients with diabetes and cardiorenal comorbidities, sodium\u2013glucose cotransporter 2 inhibitors (SGLT2is) and glucagon\u2010like peptide 1 receptor agonists (GLP\u20101 RAs) are critical to secondary outcome prevention. This study investigated physicians' adherence to current cardiorenal\u2010diabetic prescription guidelines for such patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This observational, retrospective\u2010cohort, single\u2010center study enrolled 7,805 adults (mean age 71\u2009years; mean HbA1c level 7.4%) with type 2 diabetes mellitus and atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), or chronic kidney disease (CKD). Patients' demographic information, comorbidities, medication history, and laboratory data were collected. Physician adherence was defined as a patient with ASCVD receiving an SGLT2i or GLP\u20101 RA and a patient with CKD or HF receiving an SGLT2i. The baseline characteristics of the adherence and nonadherence groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 28.4% of prescriptions adhered to guidelines. Patients in the physician\u2010adherent group had higher HbA1c levels, body mass index, and age, and more comorbidities. Logistic regression revealed that older age [odds ratio (OR) 2.29, 95% confidence interval (CI) 2.014\u20132.604, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001], cerebrovascular accident history (OR 1.591, 95% CI 1.357\u20131.865, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and dipeptidyl peptidase 4 inhibitor use (OR 2.359, 95% CI 2.062\u20132.700, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were associated with physician nonadherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only a suboptimal percentage of patients with diabetes and cardiorenal disease in Taiwan receive SGLT2is and GLP\u20101 RAs despite these medications' recognized cardiorenal benefits. Further action is required to improve physician adherence in patients with greater age, cerebrovascular accident history, and dipeptidyl peptidase 4 inhibitor use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.70090","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T10:49:21Z","timestamp":1748602161000},"page":"1535-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suboptimal physician adherence to evidence\u2010based guidelines for managing cardiorenal comorbidities in diabetes care: A retrospective single\u2010center study in Taiwan"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7754-6857","authenticated-orcid":false,"given":"Zong\u2010Yu","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3350-6548","authenticated-orcid":false,"given":"Horng\u2010Yih","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Biochemistry and Molecular Biology, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"IDF Diabetes Atlas","author":"Magliano DJ","year":"2021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0728-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01516-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14162"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31149-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022190"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1815"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.03.024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.978345"},{"key":"e_1_2_7_17_1","article-title":"Assessing the compliance of physicians with the American Diabetes Association (ADA) guidelines in prescribing cardioprotective antihyperglycemic agents to diabetic patients at a University Hospital in Jeddah, Saudi Arabia","volume":"15","author":"Sheikh AM","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-022-01672-4"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"S158","article-title":"9. 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