{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:55Z","timestamp":1787067715872,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study was to ascertain the clinical performance of OIP5\u2010AS1 in diabetic retinopathy (DR) and its molecular mechanism in the disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Subjects included 85 healthy controls, 79 patients with type 2 diabetes mellitus (T2DM), and 114 T2DM\u2010DR patients. qRT\u2010PCR was conducted to measure the relative abundances of OIP5\u2010AS1 and miR\u2010181a\u20105p in the research subjects. Receiver operating characteristic (ROC) and logistic regression analyses were employed for the diagnostic capability and risk factor prediction. Cell activities were assessed using CCK\u20108 and transwell assays. Luciferase reporter assay was used for the correlation confirmation of OIP5\u2010AS1 and miR\u2010181a\u20105p. Bioinformatic analysis was applied to predict the potential targets of miR\u2010181a\u20105p.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant decrease of OIP5\u2010AS1 was detected in serum from patients with T2MD and T2DM\u2010DR (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), exhibiting a high diagnostic value for detecting T2DM (AUC\u2009=\u20090.973) and T2DM\u2010DR patients (AUC\u2009=\u20090.913). OIP5\u2010AS1 was an independent protective indicator for the onset of T2DM\u2010proliferative DR (T2DM\u2010PDR;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021, OR\u2009=\u20090.306, 95%CI\u2009=\u20090.112\u20130.837). OIP5\u2010AS1 was markedly reduced in human retinal vascular endothelial cells (HRVECs) with high glucose (HG) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Overexpression of OIP5\u2010AS1 could significantly suppress the cell growth of HRVECs (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). OIP5\u2010AS1 was negatively correlated with miR\u2010181a\u20105p (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.5327,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, the impacts caused by OIP5\u2010AS1 on cell events were canceled by transfection of miR\u2010181a\u20105p mimic (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The possible targets of miR\u2010181a\u20105p were mined, suggesting mainly enriched in cellular senescence and the MAPK signaling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OIP5\u2010AS1 was downregulated in T2DM\u2010DR patients and regulated cellular functions via targeting miR\u2010181a\u20105p. It might offer a new therapeutic target for the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70091","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:40:26Z","timestamp":1756744826000},"page":"1993-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dysregulation of\n                    <scp>lncRNA OIP5<\/scp>\n                    \u2010\n                    <scp>AS1<\/scp>\n                    participants in the progression of diabetic retinopathy and affects the proliferation in retinal vascular endothelial cell"],"prefix":"10.1111","volume":"16","author":[{"given":"Ziwen","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Luohe Municipal Hospital  Luohe China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Luohe Municipal Hospital  Luohe China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachao","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Luohe Municipal Hospital  Luohe China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Luohe Municipal Hospital  Luohe China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nursing Luohe Municipal Hospital  Luohe China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8133-5946","authenticated-orcid":false,"given":"Qiuyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Luohe Municipal Hospital  Luohe 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