{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:44:30Z","timestamp":1780386270838,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to examine the association between insulin resistance (IR) and post\u2010stroke depression (PSD) occurrence in diabetic patients, providing novel insights for PSD prevention and treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Clinical data from 124 patients with acute cerebral infarction and diabetes mellitus were retrospectively analyzed. Based on the Homeostasis Model Assessment of Insulin Resistance (HOMA\u2010IR), participants were stratified into two groups: an IR group (HOMA\u2010IR\u2009&gt;\u20092.69, <jats:italic>n<\/jats:italic>\u2009=\u200996) and a control group (HOMA\u2010IR\u2009\u2264\u20092.69, <jats:italic>n<\/jats:italic>\u2009=\u200928). The occurrence of PSD was compared between the two groups by unadjusted analysis and inverse probability of treatment weighting (IPTW), and the correlation between HOMA\u2010IR scores and PSD was analyzed by multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3\u2010month follow\u2010up, the IR group exhibited significantly higher Hamilton Depression Scale (HAMD) scores (median 8 vs 6, <jats:italic>P<\/jats:italic>\u2009=\u20090.029) and a 3.28\u2010fold increased PSD risk (OR\u2009=\u20093.28, 95% CI: 1.37\u20137.88, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). After adjusting for baseline confounders using IPTW, the IR group maintained elevated PSD risk (adjusted OR\u2009=\u20092.64, <jats:italic>P<\/jats:italic>\u2009=\u20090.035). Multivariate analysis confirmed HOMA\u2010IR as an independent PSD predictor (OR\u2009=\u20091.755, 95% CI: 1.360\u20132.263, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), with ROC analysis demonstrating moderate predictive accuracy (AUC\u2009=\u20090.76, 51.4% sensitivity, 94.2% specificity at cutoff 5.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated HOMA\u2010IR levels in diabetic patients with acute cerebral infarction are significantly associated with increased PSD incidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.70097","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T08:44:35Z","timestamp":1750236275000},"page":"1704-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of insulin resistance on post\u2010stroke depression and outcomes in 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