{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:30:34Z","timestamp":1789414234946,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Cross\u2010sectional area (CSA) by high\u2010frequency ultrasound (HF\u2010US) detects morphologic changes in neuropathy. microRNA (miR)\u201092a\u20103p is linked to diabetes and nerve damage. Our study evaluated the diagnostic use of CSAs along with miR\u201092a\u20103p in diabetic peripheral neuropathy (DPN) and its relationship to the condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 172 patients were enrolled, comprising 89 with DPN and 83 T2DM cases without DPN. Real\u2010time quantitative polymerase chain reaction (RT\u2010qPCR) was utilized to quantify serum miR\u201092a\u20103p levels. HF\u2010US detected CSA in the median, ulnar, and tibial nerves. Logistic regression analyzed potential risk factors for DPN occurrence and severity. Receiver operating characteristic curves assessed the diagnostic significance of miR\u201092a\u20103p and CSAs for DPN. Pearson coefficients evaluated the correlation between the Toronto Clinical Scoring System (TCSS) score and miR\u201092a\u20103p or CSAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DPN patients had significantly higher serum miR\u201092a\u20103p levels and CSAs of the median, tibial, and ulnar nerves than T2DM patients. Moreover, miR\u201092a\u20103p and CSAs were risk factors for DPN. When combined, they yielded an AUC of 0.891, with 80.90% sensitivity and 91.57% specificity, accurately identifying DPN patients. Furthermore, miR\u201092a\u20103p and CSAs correlated with TCSS score and were higher in moderate\u2010to\u2010severe patients with DPN than in mild patients with DPN. Finally, miR\u201092a\u20103p combined with CSAs predicted moderate\u2010to\u2010severe DPN with 91.67% sensitivity and 85.37% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum miR\u201092a\u20103p and CSAs of median, ulnar, and tibial nerves are elevated in DPN patients. Their combination has high diagnostic significance in identifying DPN in T2DM patients and assessing its severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.70110","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T10:36:45Z","timestamp":1751625405000},"page":"1692-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical value of high\u2010frequency ultrasound and\u00a0serum <scp>miR<\/scp>\u201092a\u20103p in diabetic peripheral neuropathy"],"prefix":"10.1111","volume":"16","author":[{"given":"Chunmei","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound The Affiliated Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Anesthesia Operation Center The Second Affiliated 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