{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:34:30Z","timestamp":1763559270268,"version":"3.45.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012627","name":"Japan Diabetes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>To clarify the relationship between medication use and primary care visit non\u2010attendance (missed appointment) among people with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data of 2,200 patients registered in the Japan Diabetes Outcome Intervention Trial\u20102 Large\u2010Scale trial were reviewed. The intervention group received multifaceted interventions encouraging regular visits. The hazard ratios (HR) and 95% confidence intervals (CI) of oral medications relative to not taking any oral medications were estimated using the Cox proportional hazards model, adjusted for district medical association ID, intervention, insulin usage, age, sex, and HbA1c. We also investigated whether the HRs differed based on the oral medication type. Furthermore, we divided the intervention and control groups into four groups based on medication use (taking\/not taking oral medications and insulin therapy) and performed survival analysis for each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HRs (95% CI) for oral medication use relative to not taking oral medications and for insulin use relative to not receiving insulin therapy were 0.178 (0.104\u20130.305) and 0.725 (0.378\u20131.352), respectively. Regardless of the type of oral medication, non\u2010attendance was lower in the groups taking oral medications. The HRs (95% CI) in the groups taking only oral hypoglycemic agents, only other drugs, and both relative to no oral medication were 0.229 (0.126\u20130.417), 0.235 (0.112\u20130.494), and 0.148 (0.084\u20130.260), respectively. Only in the control group, non\u2010attendance was more frequent with no medications than with oral medications, regardless of insulin (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that taking oral medications might be important to prevent non\u2010attendance among people with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70121","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T09:32:03Z","timestamp":1752312723000},"page":"1960-1968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between medication use and non\u2010attendance (missed appointment) from primary care visits among people with type 2 diabetes: The Japan Diabetes Outcome Intervention Trial\u20102 Large\u2010Scale Trial 006 (J\u2010\n                    <scp>DOIT2<\/scp>\n                    \u2010\n                    <scp>LT006<\/scp>\n                    )"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5344-7839","authenticated-orcid":false,"given":"Yusuke","family":"Hikima","sequence":"first","affiliation":[{"name":"Division of Nephrology and Endocrinology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-4342","authenticated-orcid":false,"given":"Ryotaro","family":"Bouchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global, Health and Medicine  Tokyo Japan"},{"name":"Diabetes and Metabolism Information Center National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Hayashino","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0669-654X","authenticated-orcid":false,"given":"Atsushi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine Yokohama City University  Kanagawa Japan"},{"name":"Department of Health Data Science, Graduate School of Data Science Yokohama City University  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikari","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Diabetes Center Japan Community Health Care Organization Takaoka Fushiki Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Kawai Clinic  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global, Health and Medicine  Tokyo Japan"},{"name":"Center for Clinical Sciences National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaomi","family":"Nangaku","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-4631","authenticated-orcid":false,"given":"Mitsuhiko","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital International University of Health and Welfare  Chiba Japan"},{"name":"Department of Endocrinology and Diabetes Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"J\u2010DOIT2 Study 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