{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:06:36Z","timestamp":1790204796466,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200500"],"award-info":[{"award-number":["82200500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride glucose\u2010body mass index (TyG\u2010BMI) has emerged as a predictor of complications in patients with heart failure (HF). While elevated TyG\u2010BMI levels have been linked to adverse outcomes in HF patients, their predictive value for acute kidney injury (AKI) risk remains unclear. This study aimed to examine the association between TyG\u2010BMI and the incidence of AKI in patients with HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Data were obtained from the Medical Information Mart for Intensive Care\u2010IV version 3.1 (MIMIC\u2010IV v3.1) and the eICU Collaborative Research Database version 2.0 (eICU\u2010CRD v2.0). The primary outcome was the occurrence of AKI, with secondary outcomes including the need for renal replacement therapy (RRT) and in\u2010hospital mortality. Kaplan\u2013Meier survival analysis, restricted cubic spline modeling, and Cox proportional hazards regression models were used to assess the associations between TyG\u2010BMI and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 1,250 patients from MIMIC\u2010IV and 2,300 patients from eICU\u2010CRD. Patients with higher TyG\u2010BMI levels had a significantly higher cumulative incidence of AKI and increased rates of RRT use and in\u2010hospital mortality. After adjusting for potential confounders, higher TyG\u2010BMI remained independently associated with an increased risk of AKI among HF patients in multivariable models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This multicenter analysis demonstrates that higher TyG\u2010BMI levels are associated with an increased risk of AKI, greater need for RRT, and higher in\u2010hospital mortality in patients with HF. TyG\u2010BMI may serve as a useful marker for early risk stratification and prognostic assessment in this population. Further prospective studies are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70133","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T10:30:27Z","timestamp":1754476227000},"page":"1844-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>TyG<\/scp>\n                    \u2010\n                    <scp>BMI<\/scp>\n                    index as a valuable risk of acute kidney injury in patients with heart failure: Insights from the\n                    <scp>MIMIC<\/scp>\n                    \u2010\n                    <scp>IV<\/scp>\n                    and\n                    <scp>eICU<\/scp>\n                    cohorts"],"prefix":"10.1111","volume":"16","author":[{"given":"Yiming","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The First Affiliated Hospital of Xi'an 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