{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:53:51Z","timestamp":1790636031139,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes management in end\u2010stage kidney disease (ESKD) is complicated by altered insulin pharmacokinetics and glucose metabolism, particularly in the context of hemodialysis (HD). Automated insulin delivery (AID) systems offer dynamic insulin adjustment and may help address these challenges. We present real\u2010world data from nine individuals (five females) with type 1 diabetes and ESKD on HD, median age 38\u2009years (range 33\u201350). Over a median follow\u2010up of 7\u2009months (range 1.5\u201325), AID use led to significant improvements in glucose time in range (3.9\u201310\u2009mmol\/l) which increased from 39.7% to 59.8% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), glucose variability decreased from 39.8% to 33.8% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01), and HbA1c improved from 78.6 to 56.1\u2009mmol\/mol (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003). Time below range fell from 4.0% to 1.4%, but this was not significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.1). AID was well tolerated and implemented with multidisciplinary support. Our findings highlight the potential of AID to improve glycemic control in this high\u2010risk population and the need for further studies in this area.\n                  <\/jats:p>","DOI":"10.1111\/jdi.70141","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:21:13Z","timestamp":1755598873000},"page":"2027-2032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Using automated insulin delivery to address the clinical challenges of glycemic management in people with type 1 diabetes and kidney failure on maintenance hemodialysis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-4911","authenticated-orcid":false,"given":"Panagiotis","family":"Pavlou","sequence":"first","affiliation":[{"name":"King's College London  London UK"},{"name":"Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Reddy","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parizad","family":"Avari","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalantha","family":"Leelarathna","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"},{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Tan","sequence":"additional","affiliation":[{"name":"King's College London  London UK"},{"name":"King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahseen A.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hyslop","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufyan","family":"Hussain","sequence":"additional","affiliation":[{"name":"King's College London  London UK"},{"name":"Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Johnston","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaka","family":"Karalliedde","sequence":"additional","affiliation":[{"name":"King's College London  London UK"},{"name":"Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.10.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00218-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1913"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0030"},{"key":"e_1_2_9_6_1","article-title":"Challenges of glycemic control in people with diabetes and advanced kidney disease and the potential of automated insulin delivery","volume":"18","author":"Lu JC","year":"2023","journal-title":"J Diabetes Sci 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Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:52:17Z","timestamp":1761976337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jdi.70141"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70141","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"2025-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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