{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:56:45Z","timestamp":1761976605803,"version":"build-2065373602"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>High 1\u2010h plasma glucose levels have an increased risk of type 2 diabetes. To determine the pathophysiological features in participants with normal glucose tolerance (NGT) with 1\u2010h hyperglycemia (HG), we investigated the variability in the glucagon and insulin secretions after oral glucose loading and nutrient survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A 75\u2010g oral glucose tolerance test (OGTT) was performed in Japanese Americans (aged 40\u201375\u2009years), enrolled in medical surveys conducted in 2015. We recruited only participants with NGT defined as fasting glucose values &lt;110\u2009mg\/dL and 2\u2010h glucose levels &lt;140\u2009mg\/dL. We evaluated homeostatic model assessment for insulin resistance (HOMA\u2010IR), insulin sensitivity index (MATSUDA\u2010Index), insulin, and glucagon (GCG) secretions during the 75\u2010g OGTT and compared them between 1\u2010h serum glucose values: &lt;155\u2009mg\/dL (1\u2010h non\u2010hyperglycemia: NHG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976) and 1\u2010h serum glucose values: \u2265155\u2009mg\/dL (HG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941). We also conducted a dietary intake survey to determine the association between 1\u2010h serum glucose and nutritional intake in the usual diet.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The HG group demonstrated significant insulin resistance compared to the NHG group. Two\u2010h GCG levels were significantly lower in the HG group. Additionally, low vegetable fat intake was significantly associated with 1\u2010h HG after adjusting for sex, age, and body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Insulin resistance is already present in the HG group. Vegetable fat intake may be associated with glucose metabolism regardless of clinical background.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70148","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:25:14Z","timestamp":1756995914000},"page":"2018-2026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics of Japanese Americans with normal glucose tolerance with 1\u2010h hyperglycemia: A cross\u2010sectional study"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-6416","authenticated-orcid":false,"given":"Natsumi","family":"Himeno","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetic Medicine Hiroshima University Hospital  Hiroshima Japan"},{"name":"Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences Hiroshima University  Hiroshima 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