{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:38:55Z","timestamp":1793389135241,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the association between time in range (TIR) and mild cognitive impairment (MCI) in older adult patients with type 2 diabetes mellitus (T2DM) and the contributions of various indicators to MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Two hundred and three participants received continuous glucose monitoring and cognitive assessments. Relative weight analysis assessed TIR and other factors\u2019 contributions to MCI. Binary logistic analysis explored TIR\u2010MCI associations across the sample and by age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TIR showed a stronger association with MCI than diabetes duration, education, systolic blood pressure (SBP), urinary albumin\u2013creatinine ratio (UACR), and C\u2010peptide (25.59% relative weight). Multivariable\u2010adjusted odds ratios (ORs) for MCI declined with increasing TIR quartile (Q) (Q1 [reference group], \u226440%; Q2, 40.3\u201351.1%, OR 0.402, 95% confidence interval [CI] 0.094\u20131.717; Q3, 51.2\u201361.2%, OR 0.113, 95% CI 0.023\u20130.565; Q4, \u226561.3%, OR 0.050, 95% CI 0.007\u20130.343). This protective association remained when TIR was treated as a continuous variable and adjusted for covariates\u00a0(OR 0.917, 95% CI 0.867\u20130.969,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Women with TIR \u226561.3% had lower MCI risk. Men with TIR 51.2\u201361.2% had lower MCI risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Besides hemoglobin A1c, clinicians should consider low TIR as a risk factor for MCI in older T2DM patients. Women potentially require a higher TIR target to prevent MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70161","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T07:05:31Z","timestamp":1758956731000},"page":"2225-2233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation between time in range and mild cognitive impairment in older adults with type\u00a02 diabetes mellitus"],"prefix":"10.1111","volume":"16","author":[{"given":"Jiajun","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Endocrinology Rugao People's Hospital  Rugao Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Medical Statistics, School of Public Health Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Rugao People's Hospital  Rugao Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Rugao People's Hospital  Rugao Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Medical Statistics, School of Public Health Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530323666230915100355"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115802"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1195962"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01170-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i4.120"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108072"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.12.5.365"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0427-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0063"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0310"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1444"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30136-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191217"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-04986-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03242-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-024-01772-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115748"},{"key":"e_1_2_9_24_1","first-page":"1187","article-title":"Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR\u2010126 and miR\u2010342 levels","volume":"34","author":"Xi W","year":"2021","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.09.007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnha.2024.100252"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0389"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132118"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123906"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2038"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.151"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-018-09830-1"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.5.E924"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.12.019"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02424.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.07.013"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.09.008"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.01.006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0016"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1044-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MEBR.0000043967.78763.5b"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4862-9"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4502-1"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0758"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.884579"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.70089"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102834"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010025\u201003129\u20103"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4939-5"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05891-x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30263-2"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01718-y"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:49:15Z","timestamp":1764931755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,27]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jdi.70161"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70161","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,27]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}