{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:54:12Z","timestamp":1789419252634,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The renoprotective effects of luseogliflozin, a sodium\u2010glucose cotransporter 2 inhibitor, in patients with renal dysfunction are unexamined. We evaluated the efficacy of luseogliflozin in slowing renal function decline among patients with type 2 diabetes mellitus and moderate to severe renal dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In a multicenter, randomized, open\u2010label, controlled clinical trial, patients with type 2 diabetes mellitus and an estimated glomerular filtration rate based on serum creatinine (eGFRcreat) of 15\u201345\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      were randomized into luseogliflozin or control groups. The primary endpoint was the change in eGFRcreat from baseline to 104\u2009weeks. Secondary endpoints included eGFRcreat and eGFRcreat slope changes from 4 to 104\u2009weeks (chronic eGFRcreat slope).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 152 participants, eGFRcreat change from baseline to 104\u2009weeks did not significantly differ between groups. The luseogliflozin group showed a significant decrease in eGFRcreat from 2 to 12\u2009weeks compared to the control group; the largest decline occurred at 4\u2009weeks (initial eGFR decline). There were no differences between groups thereafter. The chronic eGFRcreat slope was less negative in the luseogliflozin group compared to the control group (not significant). Conversely, subgroup analysis indicated that the difference in chronic eGFRcreat slope between groups was significantly greater (with a less negative or even positive slope observed in the luseogliflozin group compared to the control group) among patients with eGFRcreat &lt;30\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , urinary albumin\/creatinine ratio &lt;30\u2009mg\/g creatinine, systolic blood pressure &lt;130\u2009mmHg, or females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although the primary endpoint did not reach statistical significance,\n                      <jats:bold>l<\/jats:bold>\n                      useogliflozin may provide renoprotective benefits in patients with type 2 diabetes mellitus and moderate\u2010to\u2010severe renal impairment, potentially by slowing eGFRcreat decline post\u2010initial decline.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70173","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:27:07Z","timestamp":1760005627000},"page":"2160-2172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of luseogliflozin for renal function preservation in patients with type 2 diabetes mellitus and impaired renal function: A randomized open\u2010label clinical trial (\n                    <scp>RESOLUTION<\/scp>\n                    study)"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0199-1650","authenticated-orcid":false,"given":"Munehiro","family":"Kitada","sequence":"first","affiliation":[{"name":"Department of Nephrology, School of Medicine Wakayama Medical University  Wakayama Japan"},{"name":"Hamada Medical Clinic  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4142-1218","authenticated-orcid":false,"given":"Masao","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Metabolism, Department of Internal Medicine Tokai University School of Medicine  Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Omi Medical Center  Kusatsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"STOP DM Suzuki Diabetes Clinic  Atsugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Okada","sequence":"additional","affiliation":[{"name":"Clinical Research Center Hospital of the University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikata","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology Nagahama City Hospital  Nagahama Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Kumanomae Nishimura Medical Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Department of Internal Medicine Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinari","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanazawa University Graduate School of Medical Sciences  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohide","family":"Isono","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Department of Internal Medicine JCHO Shiga Hospital  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Onoue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3538-3163","authenticated-orcid":false,"given":"Kenichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Diabetes Wakamatsu Hospital of the University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaji","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keiju Medical Center  Nanao Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Omura","sequence":"additional","affiliation":[{"name":"Division of Diabetology, Endocrinology and Metabolism, Department of Internal Medicine Kohka Public Hospital  Koka City Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-7687","authenticated-orcid":false,"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimichi","family":"Asano","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine Ishikawa Prefectural Central Hospital  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Wakasa","sequence":"additional","affiliation":[{"name":"Wakasa Medical Clinic  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Center for Innovative Clinical Medicine Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Medicine Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Kanazawa Medical University Himi Municipal Hospital  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"RESOLUTION Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27699"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14789\/jmj.2019.65.JMJ19-R16"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13895"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008121270"},{"key":"e_1_2_9_6_1","first-page":"751","article-title":"Diabetic kidney disease: Diagnosis, treatment, and prevention","volume":"99","author":"McGrath K","year":"2019","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-023-02376-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8859678"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.6634"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010596"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.03.033"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204233"},{"key":"e_1_2_9_15_1","first-page":"777","article-title":"Long\u2010term effects of Empagliflozin in patients with chronic kidney disease","volume":"392","author":"Herrington WG","year":"2024","journal-title":"N Engl J Med"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-024-02489-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00321-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.456"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.08.019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1309-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.10.025"},{"key":"e_1_2_9_23_1","first-page":"559","article-title":"Evaluation of the safety and efficacy of SGLT2 inhibitor luseogliflozin in elderly patients with type 2 diabetes mellitus\u2010post\u2010marketing surveillance in elderly patients (final report)","volume":"45","author":"Kurose K","year":"2017","journal-title":"Jpn Pharmacol Ther"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-089783"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00242-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019111168"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10924"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12977"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23331"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004007"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2023-003836"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.8029"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14562"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1356"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.020"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:49:17Z","timestamp":1764931757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jdi.70173"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70173","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}