{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T02:13:41Z","timestamp":1783822421414,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["ZDYN\u20102024\u2010B\u2010037"],"award-info":[{"award-number":["ZDYN\u20102024\u2010B\u2010037"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Diabetic foot ulcers (DFUs) have increasingly affected younger populations. This study aimed to analyze the clinical characteristics of DFUs in different age groups of diabetic patients with foot ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study of diabetic patients with foot ulcers admitted to West China Hospital, Sichuan University. They were divided into the young (&lt;45\u2009years), the middle\u2010aged (45\u201364\u2009years), and the elderly groups (\u226565\u2009years). The patients were followed up for a median of 44.5\u2009months, either at the outpatient department or by phone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study enrolled 1,209 patients with DFUs, stratified into three groups according to age: young (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965), middle\u2010aged (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009509), and elderly (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009635). All patients had a long history of diabetes with an average duration of 11.5\u2009years. The DFU patients of all ages have poor glycemic control. About one\u2010third of the patients have recurrent foot ulcers. The prevalence of comorbidities such as hypertension, coronary artery disease, chronic kidney disease, and peripheral artery disease increased significantly with age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Neuropathic foot ulcers were more common in the young patients (48.3%), whereas neuro\u2010ischemic ulcers were more prevalent in the middle\u2010aged (42.1%) and elderly patients (56.9%). Compared with the young (27.7%) and middle\u2010aged patients (26.9%), the ulcer healing rates during hospitalization were significantly lower in the elderly patients (18.9%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). During a median 44.5 (IQR 18.7\u201374.5)\u2010month follow\u2010up period, 375 (36.2%) deaths occurred, and all\u2010cause mortality increased significantly with age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical characteristics of DFUs are profoundly age\u2010dependent: younger patients exhibited poorer glycemic control, neuropathic ulcers, and mechanical injuries, while the older patients developed more vascular complications and neuro\u2010ischemic ulcers. Therefore, different prevention and treatment measures should be taken for DFUs based on their clinical characteristics in different age groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70181","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:08:09Z","timestamp":1762348089000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age\u2010related variations in clinical characteristics of patients with diabetic foot ulcers"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-2650","authenticated-orcid":false,"given":"Hong\u2010ping","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Diabetic Foot Care Center, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"International Medical Center Ward, General Practice Medical Center, West 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