{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:16:51Z","timestamp":1784287011125,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K18640"],"award-info":[{"award-number":["24K18640"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016573","name":"Japan Association for Diabetes Education and Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016573","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Among patients with diabetes receiving sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors, HbA1c levels are higher than glycated albumin levels. This study therefore aimed to evaluate the discrepancy between HbA1c and glucose management indicator (GMI), an index of glucose management derived from continuous glucose monitoring, in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study included patients with diabetes in whom HbA1c and GMI were simultaneously measured at two Japanese institutions. Data were collected when HbA1c levels had stabilized for at least 6\u2009months after the administration of an oral hypoglycemic agent. The primary outcome was the discrepancy between HbA1c and GMI among patients receiving SGLT2 inhibitors and those receiving other oral hypoglycemic agents. Inverse probability of treatment weighting (IPTW) was used to adjust for confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 136 patients were included; of these, 109 and 27 were included in the SGLT2 inhibitor group and control group, respectively. After IPTW adjustment, the discrepancy between HbA1c and GMI (HbA1c\u2013GMI) was significantly higher in the SGLT2 inhibitor group than in the control group (\u03b2\u2009=\u20090.42; 95% confidence interval 0.14\u20130.70;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients receiving SGLT2 inhibitors may have increased HbA1c relative to their actual glycemic control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70191","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:09:51Z","timestamp":1763114991000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased\n                    <scp>HbA1c<\/scp>\n                    relative to actual glycemic control in patients treated with sodium\u2013glucose cotransporter 2 inhibitors"],"prefix":"10.1111","volume":"17","author":[{"given":"Keigo","family":"Mizutani","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eita","family":"Uenishi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Uenishi Diabetes and Thyroid Clinic  Komaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-9937","authenticated-orcid":false,"given":"Takeshi","family":"Onoue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Clinical Research Education Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Education Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Nephrology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Education Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3746-1997","authenticated-orcid":false,"given":"Hiroshi","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01064-K"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30327-3"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"S83","article-title":"Glycemic targets: Standards of medical care in diabetes\u20102022","volume":"45","author":"Committee ADAPP 6","year":"2022","journal-title":"Diabetes Care"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13306"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90019-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13345"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.25.1.1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154112"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1712"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000272"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1581"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968221092050"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2020.0501"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(02)00226-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00284"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.35.2.377"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1087"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.4511"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108225"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00319-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S007"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1844"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00191"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S007"},{"key":"e_1_2_8_29_1","unstructured":"Society TJD.Clinical guidelines for appropriate use of continuous glucose monitoring devices.2024Available from:https:\/\/www.jds.or.jp\/uploads\/files\/document\/cgm\/CGM_usage_guideline_2024\u201005\u201015.pdf. Accessed August 25 2025."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-001115"},{"key":"e_1_2_8_31_1","unstructured":"AstraZeneca.Forxiga approved in Japan for type\u20101 diabetes [media release].2019Available from:https:\/\/www.astrazeneca.com\/media\u2010centre\/press\u2010releases\/2019\/forxiga\u2010approved\u2010in\u2010japan\u2010for\u2010type\u20101\u2010diabetes\u201027032019.html. Accessed September 29 2025."},{"key":"e_1_2_8_32_1","unstructured":"Astellas.Approval of Suglat\u00ae Tablets Selective SGLT2 Inhibitor for Additional Indication of type 1 diabetes mellitus and Additional dosage and administration in Japan [media release].2018Available from:https:\/\/www.astellas.com\/en\/news\/20041. Accessed September 29 2025."},{"key":"e_1_2_8_33_1","unstructured":"Japan Association for Diabetes Education and Care.Recommendations for the Appropriate Use of SGLT2 Inhibitors in the Treatment of Diabetes (in Japanese).2022Available from:https:\/\/www.nittokyo.or.jp\/modules\/information\/index.php?content_id=22. Accessed September 29 2025."},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-020-00971-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ21-0573"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.060511"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044235"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T08:13:52Z","timestamp":1767341632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jdi.70191"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70191","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}