{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:29:40Z","timestamp":1793255380916,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A 48\u2010year\u2010old man was referred to our hospital due to hyperglycemia. His casual plasma glucose and glycated hemoglobin A1c were 25.2\u2009mmol\/L and 8.7%, respectively. He had undergone bilateral cataract surgery in his 30s. He exhibited a bird\u2010like face contour, gray hair, alopecia, and bilateral calcifications of the Achilles' tendons, suggestive of Werner syndrome (WS). Genetic analysis revealed compound heterozygous mutations in the\n                    <jats:italic>WRN<\/jats:italic>\n                    gene (mutation c. 3139\u20101G&gt;C, mutation c. 1105C&gt;T), leading to the diagnosis of WS. Adequate glycemic control was not achieved by the treatment with pioglitazone and metformin. Additional administration of dapagliflozin, a sodium\u2010glucose cotransporter 2 inhibitor, ameliorated insulin resistance and resulted in an improvement in glycemic control without adverse events. Dapagliflozin may potentially be a choice in treating diabetes associated with WS with an amelioration of insulin resistance.\n                  <\/jats:p>","DOI":"10.1111\/jdi.70203","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:49:53Z","timestamp":1764402593000},"page":"366-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of\n                    <scp>SGLT2<\/scp>\n                    inhibitor on insulin resistance and hyperglycemia in Werner syndrome\u2014A case report"],"prefix":"10.1111","volume":"17","author":[{"given":"Takashi","family":"Yagi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya 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