{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:16:35Z","timestamp":1770084995855,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigates the impact of glycemic variability on sudomotor dysfunction in type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 206 type 2 diabetes mellitus patients and 34 healthy controls were included. Sweat function (SF) was assessed using electrochemical conductance of hands (HESC) and feet (FESC). Type 2 diabetes mellitus patients underwent continuous glucose monitoring (CGM), and blood glucose variability was analyzed using various metrics. Type 2 diabetes mellitus patients were classified into normal, abnormal, reversible, and persistent abnormal SF groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In healthy controls, SF showed no circadian rhythm. Type 2 diabetes mellitus patients with abnormal SF had longer diabetes duration, higher glucose variability, and greater SF impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The reversible group exhibited the largest SF fluctuations (~26 \u03bcS) and a significant correlation between glucose variability and SF (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Blood glucose levels of 5\u201310\u2009mmol\/L were associated with improved SF in this group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings suggest that greater glucose variability correlates with more severe peripheral nerve damage, and controlling blood glucose within 5\u201310\u2009mmol\/L may improve SF, offering insights for personalized treatment strategies in diabetic peripheral neuropathy (DPN) prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70211","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T12:44:52Z","timestamp":1766148292000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of glycemic variability on early detection of sudomotor dysfunction: Implications for early intervention and personalized treatment"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-6349","authenticated-orcid":false,"given":"Yang","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism First People's Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology)  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Wenjiang District Traditional Chinese Medicine Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6115-537X","authenticated-orcid":false,"given":"Zhi","family":"Liang","sequence":"additional","affiliation":[{"name":"Information Center First People's Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology)  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Practice Shanghai Jing'an District Central Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5749-3909","authenticated-orcid":false,"given":"Yi\u2010kun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism First People's Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology)  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0473-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2013.08.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0063"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7489795"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-002032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-018-0371-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.01.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1775-8251"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0129"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.02.013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0224"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.03.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1433512"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0613"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.11.2795"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.02.087"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.12.179"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-023-00973-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.07.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0671-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2549"},{"key":"e_1_2_9_24_1","first-page":"476","article-title":"Correlation between glycemic variability and sudomotor function in patients with type 2 diabetes","volume":"10","author":"Sun J","year":"2018","journal-title":"Chin J Diabetes"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-003005"},{"key":"e_1_2_9_26_1","article-title":"The importance of evaluating sudomotor function in the diagnosis of cardiac autonomic neuropathy","volume":"16","author":"Nica AE","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-016-0900-y"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:38:04Z","timestamp":1770039484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jdi.70211"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70211","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}