{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:16:35Z","timestamp":1770084995829,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus and may be linked to renal function decline. However, the prognostic value of point\u2010of\u2010care nerve conduction devices such as DPN\u2010Check\u00ae for renal outcomes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single\u2010center retrospective observational study of 403 patients with diabetes (median follow\u2010up 2.9\u2009years) at Tokyo Metropolitan Ohkubo Hospital. DPN was assessed by DPN\u2010Check\u00ae (amplitude [AMP] &lt;5\u2009\u03bcV or nerve conduction velocity [NCV] &lt;42\u2009m\/s) and simplified diagnostic criteria (SDC). The primary outcome was annual eGFR decline, calculated by the linear least squares method; rapid decliners were defined as those with a decline \u22655\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      \/year. Multivariate linear and logistic regression analyses were performed to identify independent associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with DPN diagnosed with DPN\u2010Check\u00ae had a greater annual eGFR decline than those without (\u22122.26 vs. \u22120.81\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      \/year,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas DPN diagnosed with SDC showed no association. In multivariate analysis, DPN diagnosed with DPN\u2010Check\u00ae remained independently associated with faster eGFR decline (standardized \u03b2: \u22120.262,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and with rapid decliner status (odds ratio [OR]: 2.791, 95% confidence interval [CI]: 1.267\u20136.152,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DPN diagnosed by DPN\u2010Check\u00ae was independently associated with accelerated renal function decline in patients with T2DM, even after adjusting for albuminuria. DPN\u2010Check\u00ae may help identify patients at high risk for end\u2010stage kidney disease and guide earlier intervention for both neuropathy and kidney disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70212","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T14:43:20Z","timestamp":1764513800000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diabetic peripheral neuropathy as measured using a point\u2010of\u2010care sural nerve conduction device is associated with a faster decline in renal function in patients with type 2 diabetes"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-317X","authenticated-orcid":false,"given":"Tatsuya","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Tokyo Metropolitan Okubo Hospital  Tokyo 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Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences, Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Tokyo Metropolitan Okubo Hospital  Tokyo 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