{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:24:22Z","timestamp":1773015862581,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report long\u2010term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55\u2010year\u2010old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high\u2010dose insulin and recombinant human insulin\u2010like growth factor\u20101. Serological testing showed type B insulin resistance syndrome associated with systemic lupus erythematosus. Glucocorticoids and mycophenolate\/azathioprine combination therapy were introduced, resulting in a prompt improvement in glycemic control. The patient has remained in clinical and serological remission for 8\u2009years. Over the past year, he achieved euglycemia with azathioprine monotherapy, without the need for insulin or oral antiglycemic agents.<\/jats:p>","DOI":"10.1111\/jdi.70225","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:35:26Z","timestamp":1766748926000},"page":"542-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term remission of type B insulin resistance syndrome with immunotherapy: A\u00a0case report"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6909-4993","authenticated-orcid":false,"given":"Erika","family":"Egawa","sequence":"first","affiliation":[{"name":"Division of Diabetes and Endocrinology Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Karasawa","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Takaya","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000263"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13171"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00292"},{"key":"e_1_2_6_6_1","first-page":"337","article-title":"Type B insulin resistance syndrome: a systematic review","volume":"64","author":"Martins LM","year":"2020","journal-title":"Arch Endocrinol Metab"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3552"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0167"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-022-00570-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad461"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:28:50Z","timestamp":1773012530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jdi.70225"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70225","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"2025-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}