{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T22:09:23Z","timestamp":1778364563643,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Diabetic retinopathy (DR) is a prevalent chronic complication of type 2 diabetes mellitus (T2DM), contributing significantly to vision impairment. Circular RNAs (circRNAs) have emerged as key regulators in the pathogenesis of DR. This study aimed to investigate the differential expression profiles and potential functions of circRNAs in patients with DR compared to those without DR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, prospective study, serum samples from 20 T2DM patients with DR and 20 without DR were analyzed using the Arraystar Human circRNA Expression Profile V2.0 microarray. An additional cohort of 40 patients (20 DR and 20 without DR) was used to validate selected circRNAs via quantitative reverse transcription PCR (qRT\u2010PCR). Enriched signaling pathways were identified using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. CircRNA\u2013miRNA\u2013mRNA interaction networks were constructed using bioinformatics tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 376 circRNAs were differentially expressed, including 169 upregulated and 207 downregulated circRNAs. qRT\u2010PCR validation confirmed five downregulated circRNAs and three upregulated circRNAs, which were selected for competing endogenous RNA analysis. The circRNA\u2013miRNA\u2013mRNA network analysis revealed that hsa_circRNA_407262 (also known as circRNA LOC389906) may act as a miRNA sponge regulating key signaling pathways, including wingless\/integrated, gonadotropin\u2010releasing hormone, tumor necrosis factor, and rat sarcoma pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identified five downregulated and three upregulated circRNAs associated with DR. Among them, hsa_circRNA_407262 may play a crucial role in the pathological process of DR and holds potential as a candidate biomarker for early diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70241","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:03:35Z","timestamp":1769594615000},"page":"663-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression profile of circular\n                    <scp>RNAs<\/scp>\n                    in type 2 diabetes mellitus patients with retinopathy"],"prefix":"10.1111","volume":"17","author":[{"given":"Wencheng","family":"An","sequence":"first","affiliation":[{"name":"Department of Endocrinology Beijing Haidian Hospital, Beijing Haidian Section of Peking University Third Hospital  Beijing 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