{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:24:28Z","timestamp":1773015868033,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1314102"],"award-info":[{"award-number":["2018YFC1314102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the dynamic changes of soluble receptor for advanced glycation end products (sRAGE) and its relationship with \u03b2\u2010cell function and glycemic remission in newly diagnosed type 2 diabetes mellitus (T2DM) after short\u2010term intensive insulin therapy (SIIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 98 drug\u2010naive patients with newly diagnosed T2DM underwent a two\u2010week SIIT and were followed for 16\u2009weeks. Serum sRAGE was measured at baseline, after SIIT, and at the 1\u2010month follow\u2010up. HOMA\u2010\u03b2 and HOMA\u2010IR were used to reflect \u03b2\u2010cell function and insulin resistance, respectively. Pearson or Spearman correlation coefficients were used to assess the correlations, and logistic regression was applied to evaluate associations between changes in sRAGE (\u0394sRAGE) and 16\u2010week glycemic remission, adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      sRAGE levels increased significantly after SIIT (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and remained higher at 1\u2009month. The increase in sRAGE after SIIT was positively correlated with the changes in HOMA\u2010\u03b2 and negatively correlated with changes in HOMA\u2010IR. Participants who achieved glycemic remission had greater \u0394sRAGE after SIIT than those who did not (273.9\u2009\u00b1\u2009268.2 vs 76.7\u2009\u00b1\u2009257.7\u2009pg\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). In multivariate analysis, \u0394sRAGE was independently associated with remission (OR\u2009=\u20091.228 per 100\u2009pg\/mL, 95% CI 1.006\u20131.500,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.044), and the AUC of this model was 0.783 (95% CI 0.690\u20130.876).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevation of sRAGE after SIIT is independently associated with short\u2010term glycemic remission in newly diagnosed T2DM. The increase in sRAGE accompanied by an improvement in \u03b2\u2010cell function, suggests that increased sRAGE may reflect a compensatory response during metabolic recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70250","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:59:29Z","timestamp":1769594369000},"page":"439-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increase in soluble\n                    <scp>RAGE<\/scp>\n                    following intensive insulin therapy is associated with \u03b2\u2010cell functional improvement and glycemic remission in newly diagnosed type 2 diabetes"],"prefix":"10.1111","volume":"17","author":[{"given":"Qimou","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong Province 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University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong Province 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