{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:37:49Z","timestamp":1783021069422,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Preclinical heart failure (HF) (stages A and B) is common but easily overlooked in asymptomatic patients with type 2 diabetes (T2D). There is a paucity of evidence regarding how coexisting risk factors contribute to the development of HF in asymptomatic Asian patients with T2D, and there is a lack of guidance on the early identification of asymptomatic patients to help cost\u2010effectively allocate preventive therapies. The Diabetes Mellitus Heart Failure Events Analysis and Risk Tracking (DM\u2010HEART) trial, a prospective, multicenter, longitudinal cohort study, recruited asymptomatic patients with T2D and no prior HF between January 2021 and June 2024, with a minimum follow\u2010up period of 12\u2009months. The primary outcome was incident HF, defined as new\u2010onset HF (requiring either hospitalization or an urgent care visit). Secondary outcomes are measured as 3\u2010point major adverse cardiovascular events, comprised of cardiovascular death, non\u2010fatal myocardial infarction, or non\u2010fatal stroke. DM\u2010HEART will provide epidemiological data on the incidence of HF and assess the prognostic utility of clinical parameters, including N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP), for predicting incident HF events among asymptomatic patients with T2D in preclinical stages of HF. Furthermore, we aim to determine the optimal NT\u2010proBNP cut\u2010off value for predicting incident HF events in East Asian patients with diabetes.<\/jats:p>","DOI":"10.1111\/jdi.70255","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:43:18Z","timestamp":1778060598000},"page":"1154-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of incident heart failure in type 2 diabetes mellitus: Rationale and design of the\n                    <scp>DM<\/scp>\n                    \u2010\n                    <scp>HEART<\/scp>\n                    study"],"prefix":"10.1111","volume":"17","author":[{"given":"Jiun\u2010Lu","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine MacKay Memorial Hospital  Taipei City Taiwan"},{"name":"Department of Medicine, College of Medicine MacKay Medical 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Ming","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular Medical Center Far Eastern Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng\u2010Hsu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular Medical Center Far Eastern Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital Hsinchu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Yun","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital Hsinchu 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