{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:26:27Z","timestamp":1775060787229,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004014","name":"Japan IDDM network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016289","name":"Taiju Life Social Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017346","name":"Boehringer Ingelheim Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008673","name":"Yasuda Memorial Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glucose\u2010stimulated insulin secretion (GSIS) in \u03b2 cells depends critically on membrane depolarization\u2013induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx. Accordingly, the electrophysiological assessment of intact islets, where \u03b2 cells act as functional syncytia, is essential for evaluating insulin secretory dynamics. Imeglimin, an oral agent used in treating type 2 diabetes, increases insulin secretion; however, its effects on \u03b2\u2010cell electroactivity remain unclear. Here, we investigated extracellular and membrane potentials in imeglimin\u2010treated mouse islets using microelectrode array (MEA) recordings and a plasma membrane potential indicator (PMPI). Imeglimin augmented first\u2010phase insulin release and significantly increased the fraction of the plateau phase (FOPP), an MEA\u2010derived parameter reflecting secretory competence, under 11.1\u2009mM glucose. Consistent with these findings, the increase in PMPI fluorescence demonstrated enhanced membrane depolarization in response to imeglimin at high\u2010glucose concentrations. These findings indicate that imeglimin potentiates \u03b2\u2010cell electroactivity, thereby facilitating GSIS at the islet level.\n                  <\/jats:p>","DOI":"10.1111\/jdi.70265","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:35:34Z","timestamp":1771230934000},"page":"561-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of extracellular and membrane potentials in imeglimin\u2010treated islets"],"prefix":"10.1111","volume":"17","author":[{"given":"Asuka","family":"Tsurumoto","sequence":"first","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Inoue","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Ong Yajima","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zou","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-4540","authenticated-orcid":false,"given":"Junyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-4493","authenticated-orcid":false,"given":"Takahiro","family":"Tsuno","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohichi","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR) Gunma University  Maebashi 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