{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:10:57Z","timestamp":1780384257039,"version":"3.54.1"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Permanent neonatal diabetes mellitus (PNDM) is commonly caused by pathogenic variants in\n                    <jats:italic>KCNJ11<\/jats:italic>\n                    that impair insulin secretion through ATP\u2010sensitive potassium (K\n                    <jats:sub>ATP<\/jats:sub>\n                    ) channel dysfunction. Sulfonylureas (SUs) can stimulate insulin secretion and enable insulin discontinuation, but insulin withdrawal may remain difficult even under high\u2010dose SU, especially when therapy is initiated later in life. We describe a woman with\n                    <jats:italic>KCNJ11<\/jats:italic>\n                    \u2010related PNDM who achieved insulin discontinuation after adding sitagliptin, followed by further improvement with semaglutide during a five\u2010year follow\u2010up. HbA\n                    <jats:sub>1c<\/jats:sub>\n                    remained between 6.1% and 6.5% on semaglutide 0.25\u2009mg\/week, with a 60% reduction in glibenclamide and preserved endogenous insulin secretion. A transient HbA\n                    <jats:sub>1c<\/jats:sub>\n                    rise after semaglutide interruption, followed by improvement upon resumption, confirmed its reversible effect. No episodes of severe hypoglycemia or gastrointestinal adverse events occurred. This case suggests that combining insulin secretagogues targeting both K\n                    <jats:sub>ATP<\/jats:sub>\n                    \u2010dependent (triggering: SU) and K\n                    <jats:sub>ATP<\/jats:sub>\n                    \u2010independent (amplifying: incretin\u2010based therapy) pathways may provide additive or synergistic benefits in PNDM.\n                  <\/jats:p>","DOI":"10.1111\/jdi.70300","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:44:37Z","timestamp":1774946677000},"page":"1075-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five\u2010year follow\u2010up of incretin\u2010based therapy in a patient with\n                    <scp>KCNJ11<\/scp>\n                    \u2010related permanent neonatal diabetes: Achieving insulin discontinuation and sulfonylurea reduction"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-7102","authenticated-orcid":false,"given":"Toshiaki","family":"Ohkuma","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichiro","family":"Aotani","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakako","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Ago","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3593-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14318"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luae188"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2280"},{"key":"e_1_2_7_6_1","article-title":"Successful use of a GLP\u20101 receptor agonist as add\u2010on therapy to sulfonylurea in the treatment of KCNJ11 neonatal diabetes","volume":"8","author":"Hindso M","year":"2021","journal-title":"Eur J Case Rep Intern Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-1163"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:50:03Z","timestamp":1780383003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jdi.70300"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70300","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}