{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:10:14Z","timestamp":1780384214558,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) is a heterogeneous condition, and a proportion of patients show autoimmune features consistent with latent autoimmune diabetes in adults (LADA). This study assessed the prevalence of islet autoantibodies in newly diagnosed T2DM patients of Kazakh ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted in 240 patients (30\u201375\u2009years) with newly diagnosed T2DM in the Aktobe region, Kazakhstan (May 2024\u2013January 2025). Clinical data, HbA1c, and fasting C\u2010peptide were measured. Autoantibodies (GADA, ZnT8A, IA\u20102A, ICA\u2010ELISA) were determined by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 25.8% of patients were positive for at least one islet autoantibody. ZnT8A (13.3%) and GADA (5.8%) were the most frequent, while IA\u20102A and ICA\u2010ELISA were rare (0.8% each). Double positivity was observed in 4.6% of patients, and triple positivity in 0.4%. GADA was associated with lower BMI (kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), higher HbA1c, and reduced C\u2010peptide, while ZnT8A was linked to lower C\u2010peptide. Logistic regression confirmed C\u2010peptide as the main predictor of autoantibody positivity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70312","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:39:39Z","timestamp":1776789579000},"page":"970-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequency of islet autoantibody seropositivity among adults with newly diagnosed type 2 diabetes in the Kazakh population: A cross\u2010sectional study"],"prefix":"10.1111","volume":"17","author":[{"given":"Khatimya","family":"Kudabayeva","sequence":"first","affiliation":[{"name":"Department of Internal Diseases \u2116 1 West Kazakhstan Marat Ospanov Medical University  Aktobe Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6558-6178","authenticated-orcid":false,"given":"Bibigul","family":"Tleumagambetova","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases \u2116 1 West Kazakhstan Marat Ospanov Medical University  Aktobe Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerlan","family":"Bazargaliyev","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases \u2116 1 West Kazakhstan Marat Ospanov Medical University  Aktobe Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorina","family":"Vudu","sequence":"additional","affiliation":[{"name":"Nicolae Testemitanu State University of Medicine and Pharmacy  Chisinau Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"IDF Diabetes 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