{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:37:10Z","timestamp":1789983430830,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The Steno Type 1 Risk Engine (ST1RE) was developed to improve cardiovascular risk prediction in people with type 1 diabetes (T1D), but its applicability in Asian populations remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the Hong Kong Diabetes Register were analyzed. Cardiovascular risk was assessed using four models: ST1RE, the Joint Asia Diabetes Evaluation (JADE) coronary heart disease equation, Risk Equations for Complications of Type 2 Diabetes (RECODe), and the United Kingdom Prospective Diabetes Study Outcomes Model version 2 (UKPDS\u2010OM2). Associations between risk scores and incident cardiovascular disease (CVD) were examined using Cox regression, and predictive performance was evaluated using the concordance index (C\u2010index).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 172 Chinese T1D patients (50% male), with a mean age of 31.0\u2009\u00b1\u200915.8 and 9.3\u2009\u00b1\u20096.7\u2009years of T1D at baseline. Over 21.8\u2009\u00b1\u20095.78\u2009years of follow\u2010up, 16 (9.30%) patients developed CVD. All risk scores were significantly associated with incident CVD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and achieved C\u2010indices &gt;0.8, indicating good discrimination. The limited sample size reduced statistical power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ST1RE and other risk models developed for people with type 2 diabetes may be suitable for cardiovascular risk prediction in Chinese with T1D. Further investigation with a larger cohort is advised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70316","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:52:50Z","timestamp":1777449170000},"page":"1163-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the\n                    <scp>ST1RE<\/scp>\n                    risk engine in Chinese with type 1 diabetes and comparison with the\n                    <scp>JADE<\/scp>\n                    ,\n                    <scp>RECODe<\/scp>\n                    , and\n                    <scp>UKPDS<\/scp>\n                    risk scores"],"prefix":"10.1111","volume":"17","author":[{"given":"Andre KH","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia HT","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"CUHK\u2010SJTU Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6069","authenticated-orcid":false,"given":"Andrea OY","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of 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Obesity, The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric SH","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael LH","family":"Huang","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice PS","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong  Shatin Hong 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