{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:27Z","timestamp":1792000527667,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Diabetic ketoacidosis (DKA) is an acute, life\u2010threatening emergency that can arise as a complication of diabetes mellitus. We sought to examine the literature regarding capillary \u03b2\u2010OHB testing levels that can inform cut\u2010offs and help clinicians to safely and effectively exclude or identify DKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>For this narrative review with a systematic approach, MEDLINE, Embase, and Emcare databases were searched for primary studies. Included studies described capillary \u03b2\u2010OHB levels in relation to suspected DKA, for populations aged \u226516\u2009years. Exclusion criteria were non\u2010English language, animal studies or case reports, and\/or exclusive focus on serum \u03b2\u2010OHB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1,177 records identified, 11 studies met the criteria for data extraction. To exclude DKA in patients with hyperglycemia, capillary \u03b2\u2010OHB cut\u2010off values of &lt;1.0\u2009mmol\/L and &lt;1.5\u2009mmol\/L were most recommended. A capillary \u03b2\u2010OHB level &gt;3.0\u2009mmol\/L exhibited high sensitivity and specificity in detecting DKA and may be used in identifying cases of DKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Capillary testing can reliably detect \u03b2\u2010OHB levels within the DKA diagnostic threshold. While a capillary \u03b2\u2010OHB threshold of &lt;1.5\u2009mmol\/L may help clinicians exclude DKA, a capillary \u03b2\u2010OHB level &gt;3.0\u2009mmol\/L showed high sensitivity and specificity in detecting DKA. Future studies are needed to validate proposed cut\u2010offs and examine the utility of capillary \u03b2\u2010OHB testing in prehospital settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70317","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:37:16Z","timestamp":1776944236000},"page":"905-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A review of capillary \u03b2\u2010hydroxybutyrate cut\u2010off levels for the exclusion and identification of diabetic ketoacidosis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2832-1088","authenticated-orcid":false,"given":"Nghiep","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Medicine, Melbourne Medical School University of Melbourne  Parkville Victoria 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