{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:57:15Z","timestamp":1785571035679,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Monocyte dysfunction is central to the pathogenesis of diabetes. This study investigated the association between cholesterol accumulation in monocytes and diabetic complications as well as post\u2010discharge glycemic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective two\u2010part study. Study 1, a cross\u2010sectional study, included 40 patients with type 2 diabetes mellitus to assess the associations between monocyte cholesterol levels and diabetic complication indices. Study 2, a longitudinal study, included 19 patients with type 2 diabetes mellitus hospitalized for an approximately 2\u2010week educational program. Changes in monocyte cholesterol levels from admission to discharge were compared between two groups: those whose hemoglobin A1c (HbA1c) increased 3 months after discharge (HbA1c elevated group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) and those whose HbA1c decreased or remained stable (HbA1c non\u2010elevated group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Study 1, monocyte cholesterol levels correlated with the severity of diabetic complications, including carotid intima\u2010media thickness, the fibrosis\u20104 index, and retinopathy stage. In Study 2, during hospitalization, no significant change in monocyte cholesterol levels was observed in all patients, while a significant decrease was demonstrated in the HbA1c non\u2010elevated group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Monocytic cholesterol accumulation is associated with the severity of diverse diabetic complications and predicts the risk of glycemic deterioration after discharge. These findings suggest that monocytic cholesterol could serve as a novel translational biomarker for \u2018metabolic memory\u2019 and therapeutic resistance in type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70320","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:44:15Z","timestamp":1779252255000},"page":"1379-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol accumulation in monocytes is associated with the severity of diabetic complications and the efficacy of glycemic control interventions in patients with type 2 diabetes"],"prefix":"10.1111","volume":"17","author":[{"given":"Hideyuki","family":"Okuma","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Nerima Hikarigaoka Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9724-3357","authenticated-orcid":false,"given":"Takahiro","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Graduate School of Interdisciplinary Research, Faculty of Medicine University of Yamanashi  Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Kua\u2010House Isawa Isawa Hot Spring Hospital  Fuefuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-4561","authenticated-orcid":false,"given":"Kyoichiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Graduate School of Interdisciplinary Research, Faculty of Medicine University of Yamanashi  Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.19.2570"},{"key":"e_1_2_8_4_1","first-page":"S1","article-title":"Clinical practice guideline for diabetes Management in Chronic Kidney Disease","volume":"2022","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO","year":"2022","journal-title":"Kidney Int"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031217"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-02069-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1714167"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300749"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.219477"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.795868"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8241899"},{"key":"e_1_2_8_12_1","first-page":"9","article-title":"Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets. Signal transduction and targeted","volume":"9","author":"Chen R","year":"2024","journal-title":"Therapy"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164121989281"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00475-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.11.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.49791"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.801"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60595-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2015.11.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.11.2597"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14008"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:58:21Z","timestamp":1785567501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jdi.70320"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70320","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}