{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:37:49Z","timestamp":1783021069484,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The optimal blood pressure (BP) targets for patients with type 2 diabetes (T2D) remain debated among international guidelines. This retrospective cohort analysis evaluated the associations of specific systolic and diastolic BP (SBP and DBP) categories with long\u2010term mortality in patients with T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We analyzed 2,198 adults with T2D from the National Health and Nutrition Examination Survey (NHANES) 1999\u20132018. Participants were stratified by baseline SBP (&lt;130, 130\u2013140, \u2265140\u2009mmHg) and DBP (&lt;80, 80\u201389, \u226590\u2009mmHg). Multivariable Cox proportional hazards models were constructed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all\u2010cause, cardiovascular, cerebrovascular, and diabetes\u2010related mortality, adjusting for comprehensive baseline covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow\u2010up of 97.0\u2009months, an SBP \u2265140\u2009mmHg was significantly associated with elevated risks for all\u2010cause (HR\u2009=\u20091.66, 95% CI: 1.28\u20132.16), cardiovascular (HR\u2009=\u20091.53, 95% CI: 1.10\u20132.13), cerebrovascular (HR\u2009=\u20093.98, 95% CI: 1.71\u20139.27), and diabetes\u2010related mortality (HR\u2009=\u20091.84, 95% CI: 1.06\u20133.16) compared to an SBP &lt;130\u2009mmHg. Conversely, a DBP of 80\u201389\u2009mmHg was associated with significantly lower all\u2010cause (HR\u2009=\u20090.67, 95% CI: 0.46\u20130.98) and cardiovascular mortality (HR\u2009=\u20090.57, 95% CI: 0.35\u20130.93) than a DBP &lt;80\u2009mmHg, indicating a distinct J\u2010curve phenomenon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this observational study, baseline SBP &lt;140\u2009mmHg and DBP 80\u201389\u2009mmHg were associated with favorable survival outcomes in patients with T2D. These findings suggest that individualized blood pressure management warrants further investigation, taking into account the limitations of observational data and single baseline measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70321","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:54:33Z","timestamp":1777560873000},"page":"1183-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between blood pressure levels and mortality in patients with type 2 diabetes: A retrospective cohort analysis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0565-0781","authenticated-orcid":false,"given":"Zhen\u2010Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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Central Hospital China Medical University  Benxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Work Injury Insurance Service Center Yiyang Municipal Human Resources and Social Security Bureau  Yiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9019-8443","authenticated-orcid":false,"given":"Fang\u2010Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The People's Hospital of Yiyang  Yiyang 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