{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:10:33Z","timestamp":1788441033021,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006453","name":"Taisho Toyama Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the potential of sodium\u2013glucose cotransporter 2 inhibitors (SGLT2i) as a less invasive treatment option for mild diabetic macular edema (DMO) via post hoc subgroup analysis. Previous findings were derived exclusively from observational studies, and no interventional trials based on protocol\u2010defined criteria had been conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Based on the COMET trial data, this post hoc analysis targeted mild DME cases, defined by baseline central retinal thickness (CRT) \u2264375\u2009\u03bcm and best\u2010corrected visual acuity (BCVA) \u22640.155 (logMAR). Patients were randomized to SGLT2i (luseogliflozin) or sulfonylurea (SU, glimepiride) groups. Mild subgroups were compared with the corresponding non\u2010mild cases. The primary outcome was the 48\u2010week frequency of intravitreal ranibizumab injections (IVRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the CRT \u2264375\u2009\u03bcm subgroup, IVR frequency was significantly lower with SGLT2i vs SU (mean 0.5\u2009\u00b1\u20091.0 vs 4.3\u2009\u00b1\u20090.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005, adjusted\n                      <jats:sc>ancova<\/jats:sc>\n                      . Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      of 2.1). The cumulative mean number of IVRs was significantly lower in the SGLT2i group than in the SU group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004, hazard ratio 0.29, 95% confidence interval 0.12\u20130.67).\n                    <\/jats:p>\n                    <jats:p>In the BCVA \u2264\u20090.155 subgroup, whose mean CRT exceeded 400\u2009\u03bcm, no significant difference in IVR frequency was observed between the SGLT2i\u2010treated and SU\u2010treated patients. In addition, no intergroup differences were found in patients outside the mild subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this exploratory analysis, SGLT2 inhibition was associated with fewer intravitreal injections in patients meeting the CRT\u2010based mild criteria. These findings are hypothesis\u2010generating and warrant confirmation in future prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70330","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:57:16Z","timestamp":1778075836000},"page":"1120-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sodium\u2013glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the\n                    <scp>COMET<\/scp>\n                    trial"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-0934","authenticated-orcid":false,"given":"Yoko","family":"Takatsuna","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chiba Rosai Hospital  Ichihara Japan"},{"name":"Department of Ophthalmology and Vision Science Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu Japan"},{"name":"Department of Endocrinology, Haematology and Gerontology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-9993","authenticated-orcid":false,"given":"Masaya","family":"Koshizaka","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-9403","authenticated-orcid":false,"given":"Tomoaki","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koutaro","family":"Yokote","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Haematology and Gerontology Chiba University Graduate School of Medicine  Chiba 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