{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:38:23Z","timestamp":1783021103896,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the effect of sodium\u2013glucose cotransporter 2 inhibitor (SGLT2i) administration at hospital discharge on heart failure (HF) readmission among older patients (\u226575\u2009years) with HF and diabetes and to compare the effectiveness of four SGLT2is, namely, ipragliflozin, empagliflozin, canagliflozin, and dapagliflozin, with a focus on direct head\u2010to\u2010head comparisons among individual SGLT2is.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the Medical Data Vision claims database. We included 66,895 patients aged \u226575\u2009years who were emergently hospitalized for HF with comorbid diabetes between 2018 and 2022. Patients were categorized according to SGLT2i administration at discharge. Propensity score matching (PSM) was applied to adjust for baseline characteristics. The primary outcome was HF readmission, assessed using Kaplan\u2013Meier analysis and Cox proportional hazards models. Inverse probability of treatment weighting (IPTW) was used to compare the four SGLT2is.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, SGLT2i users showed a significantly lower risk of HF readmission than nonusers (hazard ratio [HR] 0.91, 95% confidence interval [CI]: 0.85\u20130.97,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). Sensitivity analysis censoring death and treatment discontinuation or initiation produced consistent results (HR 0.79, 95% CI: 0.74\u20130.85,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). An IPTW\u2010based comparison of the four agents revealed no significant differences, suggesting similar class\u2010wide effectiveness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among older patients with HF and diabetes, SGLT2i administration was associated with reduced HF readmission risk, with no meaningful differences among the four agents. These findings support a class\u2010wide effect of SGLT2i and highlight the importance of their appropriate initiation and continuation in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70335","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:15:09Z","timestamp":1778224509000},"page":"1132-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of sodium\u2013glucose cotransporter 2 inhibitors on heart failure readmission in older patients with diabetes: A Japanese claims\u2010based cohort study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3133-2784","authenticated-orcid":false,"given":"Kazuya","family":"Hiura","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Hokkaido University of Science  7\u201015\u20104\u20101 Maeda, Teine\u2010ku Sapporo Hokkaido 006\u20108590 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Masuda","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Hokkaido University of Science  7\u201015\u20104\u20101 Maeda, Teine\u2010ku Sapporo Hokkaido 006\u20108590 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Sakunami","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Hokkaido University of Science  7\u201015\u20104\u20101 Maeda, Teine\u2010ku Sapporo Hokkaido 006\u20108590 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Hokkaido University of Science  7\u201015\u20104\u20101 Maeda, Teine\u2010ku Sapporo Hokkaido 006\u20108590 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2023.05"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0947"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.038"},{"key":"e_1_2_9_6_1","article-title":"Nonpharmacological interventions for preventing rehospitalization among patients with heart failure: A systematic review and meta\u2010analysis","volume":"9","author":"Alnomasy N","year":"2023","journal-title":"SAGE Open Nurs"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-017-0824-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008687"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0697"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01191-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.07.025"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31824-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01429-5"},{"key":"e_1_2_9_15_1","article-title":"Emerging concepts in heart failure management and treatment: Focus on SGLT2 inhibitors in heart failure with preserved ejection fraction. 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