{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:57:14Z","timestamp":1785571034932,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260152"],"award-info":[{"award-number":["82260152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic kidney disease (DKD) is a frequent complication associated with diabetes. CREBRF was reported to be closely associated with endoplasmic reticulum stress. However, the upstream regulatory mechanism by which CREBRF modulates endoplasmic reticulum stress in DKD renal tubular injury is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HK\u20102 cells were treated with high glucose to construct a cellular model of DKD. C57BL\/6J mice were injected intraperitoneally with streptozotocin (STZ) to construct an animal model of DKD. Co\u2010IP was employed to assess the interactions between BTRC or NAA10 and CREBRF, as well as the levels of CREBRF acetylation and ubiquitination. Flow cytometry, EdU, and CCK\u20108 were used to detect apoptosis and proliferation. HE and PAS were performed to test renal histopathological changes. The expression of the above factors and endoplasmic reticulum stress\u2010related proteins was detected by western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CREBRF was downregulated in DKD, and overexpression of CREBRF inhibited endoplasmic reticulum stress to alleviate high glucose\u2010induced renal tubular injury. Additionally, NAA10 promoted acetylation of CREBRF, which facilitated BTRC\u2010mediated ubiquitination and degradation of CREBRF. Finally, NAA10 inhibited CREBRF to promote endoplasmic reticulum stress in high glucose\u2010induced renal tubules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NAA10 promoted acetylation of CREBRF, which facilitated ubiquitination and degradation of CREBRF by BTRC, leading to activation of endoplasmic reticulum stress and exacerbation of renal tubular injury in DKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70338","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:20:34Z","timestamp":1781007634000},"page":"1268-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>NAA10<\/scp>\n                    and\n                    <scp>BTRC<\/scp>\n                    drive\n                    <scp>CREBRF<\/scp>\n                    degradation in endoplasmic reticulum stress and renal tubular injury"],"prefix":"10.1111","volume":"17","author":[{"given":"Sitian","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Huankui Academy, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2790-4396","authenticated-orcid":false,"given":"Yanxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14030727"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0329"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1238927"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073969"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1182848"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3576"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030497"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03159-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07193-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23559"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002275"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70145"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0450-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.767135"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12882"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.456"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0100-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103530"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0168-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00032.2023"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1497449"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1020443"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3596"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002442020"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO05400D"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00305-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01439-07"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00123"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.202400018"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14120863"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121217"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-018-0173-0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-023-00665-4"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214480"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24321-3"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601228"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00507-y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413097"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109032"}],"container-title":["Journal 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