{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:57:14Z","timestamp":1785571034963,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000345524"],"award-info":[{"award-number":["RS\u20102024\u201000345524"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thiazolidinediones (TZDs) are antidiabetic agents recognized for their effectiveness in secondary cardiovascular prevention; however, their role in primary prevention remains uncertain. This study evaluated the primary cardiovascular preventive effect of TZDs in patients with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the nationwide health claims database, we conducted a cohort study including 1,958,643 adults with T2DM and no prior history of cardiovascular disease. TZD users were compared with dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i) users as active comparators. After 1:1 propensity score matching (PSM), major cardiovascular events\u2014composite of myocardial infarction (MI), stroke, hospitalization for heart failure (HF), and all\u2010cause mortality\u2014were compared using Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the PSM cohort consisting of 47,536 TZD users and 47,536 DPP\u20104i users, TZD users were associated with a lower risk of major cardiovascular events (HR 0.85, 95% CI 0.82\u20130.88). TZD users had lower risks of MI (HR 0.72, 95% CI 0.64\u20130.82), stroke (HR 0.84, 95% CI 0.78\u20130.90), and all\u2010cause mortality (HR 0.86, 95% CI 0.82\u20130.90), with no difference in HF hospitalizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TZD use was associated with a reduced risk of major cardiovascular events in T2DM patients, suggesting a potential role of TZDs in primary cardiovascular prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70341","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:26:07Z","timestamp":1779261967000},"page":"1367-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-7136","authenticated-orcid":false,"given":"Yun Young","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Neurology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Neurology Yongin Severance Hospital, Yonsei University College of Medicine  Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-0953","authenticated-orcid":false,"given":"Minyoul","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Neurology Yongin Severance Hospital, Yonsei University College of Medicine  Yongin South 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