{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:57:16Z","timestamp":1785571036384,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Capivasertib, an AKT inhibitor for advanced breast cancer, frequently induces hyperglycemia. We present a case series of three patients (two without pre\u2010existing diabetes) monitored with continuous glucose monitoring. Hyperglycemia developed within 2\u2009weeks in all cases. Continuous glucose monitoring visualized glycemic fluctuations synchronized with the \u201c4\u2010days\u2010on, 3\u2010days\u2010off\u201d cycle. A patient with low baseline homeostatic model assessment for \u03b2\u2010cell function and higher insulin resistance required insulin, whereas a patient with relatively preserved insulin action was managed with oral glucose\u2010lowering agents. These hypothesis\u2010generating observations suggest that pretreatment metabolic assessment might assist in preliminary risk stratification.<\/jats:p>","DOI":"10.1111\/jdi.70342","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:14:41Z","timestamp":1779189281000},"page":"1432-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous glucose monitoring\u2013guided management of capivasertib\u2010associated hyperglycemia: A case series of three patients"],"prefix":"10.1111","volume":"17","author":[{"given":"Hiroki","family":"Okumura","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-4342","authenticated-orcid":false,"given":"Ryotaro","family":"Bouchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"},{"name":"Diabetes and Metabolism Information Center, Diabetes Research Center National Institute of Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenju","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Breast and Medical Oncology National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Umamoto","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kodani","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Ihana\u2010Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"},{"name":"Diabetes and Metabolism Information Center, Diabetes Research Center National Institute of Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"},{"name":"Department of Research Resources, Center for Clinical Sciences Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Ohsugi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"},{"name":"Diabetes and Metabolism Information Center, Diabetes Research Center National Institute of Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-8102","authenticated-orcid":false,"given":"Kohjiro","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"},{"name":"Diabetes Research Center, Research Institute National Institute of Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Breast and Medical Oncology National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Breast and Medical Oncology National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214131"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2260"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luaf198"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-025-00841-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.6353-25"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.27173"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0343-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2024.09.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071598"},{"key":"e_1_2_7_11_1","article-title":"Capivasertib\u2010induced diabetic ketoacidosis in a patient with estrogen receptor\u2010positive\/human epidermal growth factor receptor 2\u2010negative (ER+\/HER2\u2010) metastatic breast cancer and No prior history of diabetes mellitus: A case report","volume":"16","author":"Rodriguez YE","year":"2024","journal-title":"Cureus"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:58:19Z","timestamp":1785567499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jdi.70342"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70342","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}