{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:22:15Z","timestamp":1789672935484,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>It is appreciated that current screening tools for diabetic peripheral neuropathy (DPN) often fail to detect early disease. Sudomotor (sweat gland) dysfunction, among the earliest manifestations of DPN, can be measured objectively by the SUDOSCAN\u00ae device. We compared SUDOSCAN\u00ae with conventional validated screening (Michigan Neuropathy Screening Instrument or MNSI) in type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      T1D participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009264, 46.2% male, mean age 26.3\u2009years, mean diabetes duration 13.2\u2009years) enrolled in the prospective PICTURE study (Diabetes Unit, KEM Hospital, Pune, India) underwent simultaneous assessments for sudomotor dysfunction (electrochemical skin conductance ESC &lt;60 \u03bcS indicating dysfunction) and DPN (MNSI) and were classified as: (a) MNSI abnormal (\u2018clinical DPN\u2019), (b) MNSI normal, but ESC &lt;60 (\u2018subclinical DPN) and (c) Both normal (\u2018no neuropathy\u2019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sudomotor dysfunction was more common than clinical DPN (46.2 vs 22.3%) with a sensitivity of 72.8% and specificity of 61.4% for detecting clinical DPN. Those with sudomotor dysfunction (ESC &lt;60 \u03bcS) were 4.3 times more likely to have clinical DPN compared with participants without sudomotor dysfunction (ESC \u226560 \u03bcS). Among participants with normal MNSI (i.e., without clinical DPN), subclinical DPN was detected in 38.5% and was associated with younger age, shorter duration of diabetes, anemia, vitamin D deficiency, and microvascular complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sudomotor testing is an objective and sensitive method for DPN screening in T1D, aiding early detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70345","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:44:31Z","timestamp":1781250271000},"page":"1358-1366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sudomotor dysfunction in people with type 1 diabetes with and without clinical peripheral neuropathy: A study from Pune, India"],"prefix":"10.1111","volume":"17","author":[{"given":"Rohan","family":"Shah","sequence":"first","affiliation":[{"name":"Diabetes Unit King Edward Memorial Hospital Research Centre  Pune Maharashtra India"},{"name":"Department of Paediatrics Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth  Pune Maharashtra India"},{"name":"Harvard T.H. Chan School of Public Health India Research Center  Mumbai Maharashtra India"},{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Global Health and Population Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishikesh","family":"Behere","sequence":"additional","affiliation":[{"name":"Diabetes Unit King Edward Memorial Hospital Research Centre  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboli","family":"Bhalerao","sequence":"additional","affiliation":[{"name":"Diabetes Unit King Edward Memorial Hospital Research Centre  Pune Maharashtra India"},{"name":"Global Research Cell, Dr. D. Y. Patil Dental College &amp; Hospital, Dr. D. Y. Patil Vidyapeeth (Deemed to be University)  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanat","family":"Phatak","sequence":"additional","affiliation":[{"name":"Diabetes Unit King Edward Memorial Hospital Research Centre  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Baptist","sequence":"additional","affiliation":[{"name":"Diabetes Unit King Edward Memorial Hospital Research Centre  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-2449","authenticated-orcid":false,"given":"Chinmay S.","family":"Marathe","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences Adelaide University  Adelaide South Australia Australia"},{"name":"Endocrine and Metabolic Unit Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittaranjan S.","family":"Yajnik","sequence":"additional","affiliation":[{"name":"Diabetes Unit King Edward Memorial Hospital Research Centre  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1265372"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.036137"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138224"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0129"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051477"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.03.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0528-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007543"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.02.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199806)15:6<508::AID-DIA613>3.0.CO;2-L"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2010.05.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2011.05.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12575"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.02.013"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/s22197571"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/103714"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108500"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00739-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0850"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.11.1281"},{"key":"e_1_2_10_22_1","volume-title":"SUDOSCAN\u00ae device information","author":"Impeto Medical","year":"2023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.09.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38012-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.310"},{"key":"e_1_2_10_26_1","volume-title":"The Minnesota Code Manual of Electrocardiographic Findings","author":"Prineas RJ","year":"2009"},{"key":"e_1_2_10_27_1","unstructured":"Surveillance Nutrition. 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