{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:57:14Z","timestamp":1785571034878,"version":"3.56.0"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypoxia\u2010stimulated adipose\u2010derived mesenchymal stem cells (ADSCs)\u2010derived exosomes (Hypo\u2010Exo) have a positive impact on diabetic wound healing. Neutrophil extracellular traps (NETs) can delay wound healing under diabetic hyperglycemia. This study aimed to investigate the mechanisms by which Hypo\u2010Exo influence NETs formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The dorsal excisional wound model was performed using streptozotocin\u2010induced diabetic mice. Neutrophils were treated with phorbol 12\u2010myristate 13\u2010acetate and Hypo\u2010Exo or ADSCs overexpressing H19 Exo, which were prepared for subsequent exploration. NETs formation was analyzed employing Sytox Green staining and PicoGreen dsDNA assay. Human umbilical vein endothelial cells (HUVECs) were exposed to the culture medium of neutrophils with Hypo\u2010Exo treatment. CD31 and Alpha\u2010Smooth Muscle Actin protein expression were detected by immunofluorescence staining. Long non\u2010coding RNA H19 (H19) expression was evaluated by RNA\u2010FISH analysis. The luciferase reporter gene and RNA immunoprecipitation analysis verified the interactions between miRNA\u2010130a\/b\u20103p (miR\u2010130a\/b\u20103p) and H19 or Homeobox A5\u00a0(HOXA5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hypo\u2010Exo promoted diabetic wound healing by repressing excessive NETs formation. Furthermore, Hypo\u2010Exo inhibited Toll\u2010like receptor 4 (TLR4)\/Nuclear factor \u03baB (NF\u2010\u03baB) pathway and inactivated NOD\u2010like receptor pyrin domain\u2010containing 3 (NLRP3) inflammasome. Moreover, Hypo\u2010Exo\u2010mediated inhibition of NETs formation promoted the proliferation, migration, and angiogenesis of HUVECs. H19 could interact with miR\u2010130a\/b\u20103p to generate a competing endogenous RNA regulatory network, thereby positively modulating HOXA5. Additionally, ADSCs overexpressing H19\u2010derived exosomes promoted diabetic wound healing by regulating the miR\u2010130a\/b\u20103p\/HOXA5 pathway\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypo\u2010Exo transferring H19 promoted diabetic wound healing by repressing NETs formation via the miR\u2010130a\/b\u20103p\/HOXA5 pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70352","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:29:18Z","timestamp":1780925358000},"page":"1283-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoxia\u2010preconditioned adipose\u2010derived mesenchymal stem cells\u2010derived exosomes transferring\n                    <scp>H19<\/scp>\n                    obstruct neutrophil extracellular traps formation via\n                    <scp>HOXA5<\/scp>\n                    \u2010mediated inactivation of\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    \/\n                    <scp>NLRP3<\/scp>\n                    inflammatory signaling"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8038-4566","authenticated-orcid":false,"given":"Li","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxi","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101072"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.05.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918223"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118498"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01734"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2024.134"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20240090"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3887"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.78046"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002875"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1122510"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115805"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.39.20250069"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00360"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1202463"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0252-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2018.10.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00352-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041306"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1099310"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081959"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1196-y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042406"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00942-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.62573"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-19-0242"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.11.034"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00611-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301403RR"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-02091-y"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1977556"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-023-01443-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03297-9"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113800"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb4020013"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.22164"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.679185"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.61902"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05138-4"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-023-00361-1"},{"key":"e_1_2_10_42_1","article-title":"Sphingosine\u20101\u2010phosphate derived from PRP\u2010exos promotes angiogenesis in diabetic wound healing via the S1PR1\/AKT\/FN1 signalling pathway. Burns","volume":"11","author":"Chen T","year":"2023","journal-title":"Dent Traumatol"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2023.09.12"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.050"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.03.161"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbad116"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7852"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/jdr\/1159325"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123764"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1162-3_9"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00318-7"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8852759"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.166"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.10.008"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.07.004"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083851"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0058-5"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.04.007"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.173231"},{"key":"e_1_2_10_61_1","first-page":"1187","article-title":"Ultra\u2010short cyclic peptide cy (RL\u2010QN15) acts as a TLR4 antagonist to expedite oral ulcer healing","volume":"46","author":"Ru ZQ","year":"2025","journal-title":"Zool Res"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.31083\/FBL37393"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.97150"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.05.010"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156175"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2020.03.005"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43640"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-104133"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111112"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11030259"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-4277"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO02707K"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07857-w"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:58:05Z","timestamp":1785567485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jdi.70352"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70352","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}